1904-73-0

Basic information

• Product Name: Quinazoline, 3,4-dihydro-2-phenyl-
• Synonyms: 2-Phenyl-3,4-dihydroquinazolin;2-phenyldihydroquinazoline;Quinazoline, 3,4-dihydro-2-phenyl-;2-Phenyl-3,4-dihydro-chinazolin;2-phenyl-3,4-dihydro-quinazoline;3,4-Dihydro-2-phenyl-chinazolin;2-Phenyl-3,4-dihydrochinazolin
• CAS NO: 1904-73-0
• Molecular Formula: C14H12N2
• Molecular Weight: 208.263
• Mol File: 1904-73-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Quinazoline, 3,4-dihydro-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinazoline, 3,4-dihydro-2-phenyl-(1904-73-0)
• EPA Substance Registry System: Quinazoline, 3,4-dihydro-2-phenyl-(1904-73-0)

Safety Data

• Hazardous Substances Data: 1904-73-0(Hazardous Substances Data)

Upstream product

• 895771-34-3 N-(2-aminobenzyl)benzamide 
• 107411-08-5 1-(o-tolyl)-5-phenyltetrazole 
• 68521-38-0 benzocyclohepta<1,4>oxazine 
• 4403-69-4 2-amino-1-benzylamine 
• 75407-57-7 2-benzoylamino-benzaldehyde-oxime 
• 67-68-5 dimethyl sulfoxide 
• 1527-91-9 N-phenylbenzamidine 
• 100-47-0 benzonitrile 
• 108-86-1 bromobenzene 
• 201230-82-2 carbon monoxide 
• 55661-71-7 2-phenyl-1,2,3, 4-tetrahydroquinazoline 
• 93-97-0 benzoic acid anhydride 
• 2489-03-4 tribromomethylbenzene 
• 98-08-8 α,α,α-trifluorotoluene 

Downstream Products

• 25855-20-3 2-phenylquinazoline 
• 1022-45-3 2-phenyl-4(3H)-quinazolinone 
• 55661-71-7 2-phenyl-1,2,3, 4-tetrahydroquinazoline 

Relevant articles and documents

Electrophilically activated nitroalkanes in synthesis of 3,4-dihydroquinozalines

Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop an innovative synthetic approach towards 3,4-dihydroquinazolines from readily available 2-(aminomethyl)anilines.

Base-Promoted Synthesis of 2-Aryl Quinazolines from 2-Aminobenzylamines in Water

A transition-metal-free procedure for the synthesis of a highly valuable class of heteroaromatics, quinazolines, was developed by using easily available 2-aminobenzylamines and α,α,α-trihalotoluenes. The transformation proceeded smoothly in the presence of only sodium hydroxide and molecular oxygen in water at 100 °C, furnishing a variety of 2-aryl quinazolines. The crystallization process of the crude reaction mixture for the purification of the solid products circumvents huge solvent-consuming workup and column chromatographic techniques, which make the overall process more sustainable and economical.

Acceptorless Dehydrogenation of N-Heterocycles by Merging Visible-Light Photoredox Catalysis and Cobalt Catalysis

Herein, the first acceptorless dehydrogenation of tetrahydroquinolines (THQs), indolines, and other related N-heterocycles, by merging visible-light photoredox catalysis and cobalt catalysis at ambient temperature, is described. The potential applications to organic transformations and hydrogen-storage materials are demonstrated. Primary mechanistic investigations indicate that the catalytic cycle occurs predominantly by an oxidative quenching pathway.