190595-66-5

Basic information

• Product Name: EzetiMibe IMpurity 1
• Synonyms: EzetiMibe IMpurity 1;(3'S,3R,4S)-Desfluoro EzetiMibe;EzetiMibe IMpurity 1 ((3'S,3R,4S)-Desfluoro EzetiMibe);(3R,4S)-1-(4-fluorophenyl)-3-((S)-3-hydroxy-3-phenylpropyl)-4-(4-hydroxyphenyl)azetidin-2-one;Ezetimibe Desfluorobenzene Analog;Ezetimibe Impurity 22
• CAS NO: 190595-66-5
• Molecular Formula: C24H22FNO3
• Molecular Weight: 391.4347832
• Product Categories: Aromatics, Heterocycles, Impuities, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 190595-66-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 655.0±55.0 °C(Predicted)
• Appearance: /
• Density: 1.293±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)
• PKA: 9.72±0.30(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: EzetiMibe IMpurity 1(CAS DataBase Reference)
• NIST Chemistry Reference: EzetiMibe IMpurity 1(190595-66-5)
• EPA Substance Registry System: EzetiMibe IMpurity 1(190595-66-5)

Safety Data

• Hazardous Substances Data: 190595-66-5(Hazardous Substances Data)

Usage

Description

(3R,4S)-1-(4-fluorophenyl)-3-((S)-3-hydroxy-3-phenylpropyl)-4-(4-hydroxyphenyl)azetidin-2-one is a complex organic compound with a unique molecular structure. It is characterized by its azetidinone ring, which is fused with a phenyl group and substituted with fluorine and hydroxyl groups. (3R,4S)-1-(4-fluorophenyl)-3-((S)-3-hydroxy-3-phenylpropyl)-4-(4-hydroxyphenyl)azetidin-2-one is known for its potential pharmaceutical applications due to its structural similarity to various bioactive molecules.

Uses

Used in Pharmaceutical Industry:
(3R,4S)-1-(4-fluorophenyl)-3-((S)-3-hydroxy-3-phenylpropyl)-4-(4-hydroxyphenyl)azetidin-2-one is used as an impurity in the development and manufacturing process of cholesterol absorption inhibitors, specifically for Ezetimibe (E975000). Its presence is crucial for ensuring the purity and efficacy of the final drug product, as it can impact the overall safety and effectiveness of the medication.
Used in Research and Development:
(3R,4S)-1-(4-fluorophenyl)-3-((S)-3-hydroxy-3-phenylpropyl)-4-(4-hydroxyphenyl)azetidin-2-one is also utilized in research and development for its potential applications in various therapeutic areas. Its unique structure allows scientists to study its interactions with biological targets, which may lead to the discovery of new drugs with improved pharmacological properties.
Used in Drug Synthesis:
(3R,4S)-1-(4-fluorophenyl)-3-((S)-3-hydroxy-3-phenylpropyl)-4-(4-hydroxyphenyl)azetidin-2-one can be employed as a key intermediate in the synthesis of novel drugs. Its versatile structure enables chemists to modify and optimize its properties, potentially leading to the development of new therapeutic agents with enhanced efficacy and safety profiles.