191102-87-1

Basic information

• Product Name: 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
• Synonyms: GGTI-2147;4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER;TUQRZGWNDBXSNP-SANMLTNESA-N
• CAS NO: 191102-87-1
• Molecular Formula: C28H28N4O3
• Molecular Weight: 468.55
• Product Categories: Other enzyme inhibitors and activators;A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I).;Amino Acids & Derivatives, Chiral Reagents, Heterocycles, Inhibitors
• Mol File: 191102-87-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: Soluble in DMSO
• Sensitive: Light Sensitive & Hygroscopic
• CAS DataBase Reference: 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER(191102-87-1)
• EPA Substance Registry System: 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER(191102-87-1)

Safety Data

• Hazardous Substances Data: 191102-87-1(Hazardous Substances Data)

Usage

Description

4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER is a complex organic compound with a unique molecular structure that features an imidazol-4-ylmethyleneamino group, a naphthyl benzoyl group, and a leucine methyl ester moiety. 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER is characterized by its potential interactions with various biological targets and its ability to modulate cellular processes.

Uses

Used in Pharmaceutical Industry:
4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER is used as an inhibitor of protein geranylgeranyltransferase-I and protein prenylation for the development of novel therapeutics. Its application is based on its ability to increase prelamin A accumulation by inhibiting the ZMPSTE24 protein in human fibroblasts, which can be beneficial in the treatment of certain genetic disorders.
Used in Research Applications:
In the field of cellular and molecular biology, 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER is used as a research tool to study the effects of protein prenylation inhibition on cellular processes. Its ability to increase cytosolic accumulation of Rac1 and elicit significant inhibition of GSIS from INS 832/13 cells makes it a valuable compound for investigating the role of protein prenylation in cellular signaling and function.
Used in Drug Development:
4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER is also used in the development of new drugs targeting protein prenylation pathways. Its potential to modulate these pathways can lead to the discovery of novel therapeutic agents for various diseases, including genetic disorders and cancer.