19115-30-1

Basic information

• Product Name: 1'-hydroxy-2',3'-dehydroestragole
• Synonyms: 1'-hydroxy-2',3'-dehydroestragole
• CAS NO: 19115-30-1
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.187
• Mol File: 19115-30-1.mol
• Article Data: 90

Chemical Properties

• Boiling Point: 228.88°C (rough estimate)
• Flash Point: 114.2°C
• Appearance: /
• Density: 1.0281 (rough estimate)
• Refractive Index: 1.6000 (estimate)
• CAS DataBase Reference: 1'-hydroxy-2',3'-dehydroestragole(CAS DataBase Reference)
• NIST Chemistry Reference: 1'-hydroxy-2',3'-dehydroestragole(19115-30-1)
• EPA Substance Registry System: 1'-hydroxy-2',3'-dehydroestragole(19115-30-1)

Safety Data

• Hazardous Substances Data: 19115-30-1(Hazardous Substances Data)

Usage

Description

1'-hydroxy-2',3'-dehydroestragole is a chemical compound with the molecular formula C10H12O2, which is a metabolite of estragole, a naturally occurring compound found in various herbs and spices. It has been identified as a potential genotoxic and carcinogenic compound due to its ability to induce DNA damage and mutagenic effects.

Uses

Used in Regulatory and Monitoring Applications:
1'-hydroxy-2',3'-dehydroestragole is used as a target for regulation and monitoring in food and consumer products to ensure safety and minimize potential health risks associated with its genotoxic and carcinogenic properties.
Used in Research and Development:
1'-hydroxy-2',3'-dehydroestragole is used as a subject of ongoing research to better understand its effects and develop strategies to mitigate its potential harm. This includes exploring ways to reduce its presence in food products or finding alternatives to estragole that do not carry the same risks.

Upstream product

• 2386-64-3 ethylmagnesium chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 156-60-5 trans-1,2-dichloroethylene 
• 65032-27-1 ethynylmagnesium chloride 
• 108-05-4 vinyl acetate 
• 16469-68-4 1-(4-methoxyphenyl)-2-propyn-1-one 
• 74-86-2 acetylene 
• 1066-54-2 trimethylsilylacetylene 
• 159351-36-7 1-(4-methoxyphenyl)-3-(trimethylsilyl)prop-2-yn-1-ol 
• 4301-14-8 acetylenemagnesium bromide 
• 1066-26-8 sodium acetylide 
• 624-67-9 Propargylic aldehyde 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 6552-67-6 (E)-1-(4-methoxyphenyl)-3-(4-nitrophenyl)-2-propen-1-one 
• 913811-10-6 1-methoxy-4-(1-triphenylmethoxyprop-2-ynyl)benzene 
• 104548-21-2 1-[4-(4-methoxyphenyl)-2,5-dimethylfuran-3-yl]ethanone 
• 1008132-30-6 4-(4-methoxyphenyl)-2,5-dimethyl-1-phenylpyrrole-3-carboxylic acid ethyl ester 
• 1008132-60-2 1-furfuryl-4-(4-methoxyphenyl)-2,5-dimethylpyrrole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Enantioselective [3 + 2] annulation of 4-isothiocyanato pyrazolones and alkynyl ketones under organocatalysis

An asymmetric [3 + 2] annulation reaction of 4-isothiocyanato pyrazolones with alkynyl ketones in the presence of an organic catalyst derived from a cinchona alkaloid under mild conditions is realized. This protocol provides unprecedented expeditious access to a wide range of optically active spiro[pyrroline-pyrazolones] with various electronic properties in high yields with good to excellent enantioselectivities.

Allenylidene Induced 1,2-Metalate Rearrangement of Indole-Boronates: Diastereoselective Access to Highly Substituted Indolines

A process to achieve 1,2-metalate rearrangements of indole boronate as a way to access substituted indolines in high diastereoselectivities is presented. The reaction involves the generation of a Cu–allenylidene, which is sufficiently electrophilic to induce the 1,2-metalate rearrangement. The scope of the reaction is evaluated as well as further transformations of the product.

Allylic and Allenylic Dearomatization of Indoles Promoted by Graphene Oxide by Covalent Grafting Activation Mode

The site-selective allylative and allenylative dearomatization of indoles with alcohols was performed under carbocatalytic regime in the presence of graphene oxide (GO, 10 wt percent loading) as the promoter. Metal-free conditions, absence of stoichiometric additive, environmentally friendly conditions (H2O/CH3CN, 55 °C, 6 h), broad substrate scope (33 examples, yield up to 92 percent) and excellent site- and stereoselectivity characterize the present methodology. Moreover, a covalent activation model exerted by GO functionalities was corroborated by spectroscopic, experimental and computational evidences. Recovering and regeneration of the GO catalyst through simple acidic treatment was also documented.