1912-47-6

Basic information

• Product Name: 5-METHYLINDOLE-3-ACETIC ACID
• Synonyms: 5-METHYLINDOLE-3-ACETIC ACID;(5-METHYL-1H-INDOL-3-YL)-ACETIC ACID;5-METHYLINDOLE-3-ACETIC ACID 98% (HPLC);5-Me-IAA;2-(5-Methyl-1H-indol-3-yl)acetic acid;5-METHYLINDOLE-3-ACETIC ACID(5MeIAA);5-Methyl Indole-3-acetate Acid;2-(5-methyl-1H-indol-3-yl)ethanoic acid
• CAS NO: 1912-47-6
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.21
• Product Categories: Indoles and derivatives;pharmacetical
• Mol File: 1912-47-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 151 °C
• Boiling Point: 420.8 °C at 760 mmHg
• Flash Point: 208.3 °C
• Appearance: /
• Density: 1.299 g/cm³
• Storage Temp.: 2-8°C
• PKA: 4.53±0.30(Predicted)
• CAS DataBase Reference: 5-METHYLINDOLE-3-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYLINDOLE-3-ACETIC ACID(1912-47-6)
• EPA Substance Registry System: 5-METHYLINDOLE-3-ACETIC ACID(1912-47-6)

Safety Data

• Hazardous Substances Data: 1912-47-6(Hazardous Substances Data)

Usage

Uses

5-Methylindole-3-acetic Acid is a derivative of Indole-3-acetic acid which is a plant growth regulator. It induces cell division and cell elongation that promotes plant growth.

Upstream product

• 1337870-84-4 (5-methyl-indol-3-yl)-acetic acid methyl ester 
• 65881-14-3 2-(5-methyl-1H-indol-3-yl)acetonitrile 
• 156695-43-1 (5-Methyl-1H-indol-3-yl)-oxo-acetic acid 
• 115956-14-4 2-(5-methyl-1H-indol-3-yl)-2-oxoacetyl chloride 
• 614-96-0 5-methyl-1H-indole 
• 692-29-5 Succinic semialdehyde 
• 539-44-6 N-4-methylphenylhydrazine 

Downstream Products

• 91957-21-0 5-methyl-1H-indole-3-acetic acid ethyl e 
• 39595-23-8 2-(5-methyl-1H-indol-3-yl)ethan-1-ol 
• 1383933-35-4 C₁₈H₁₈N₂O 
• 1383933-36-5 N-benzyl-2-(1,5-dimethyl-1H-indol-3-yl)acetamide 
• 924633-74-9 benzyl 3-(3-acetoxy-2-oxopropyl)-5-methyl-1H-indole-1-carboxylate 
• 924635-03-0 benzyl 3-(3-chloro-2-oxopropyl)-5-methyl-1H-indole-1-carboxylate 
• 924635-02-9 2-(1-(benzyloxycarbonyl)-5-methyl-1H-indol-3-yl)acetic acid 
• 442883-72-9 5-methyl-3-methylene-2-oxindole 
• 1337870-84-4 (5-methyl-indol-3-yl)-acetic acid methyl ester 

Relevant articles and documents

TETRAHYDROISOQUINOLINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF

Disclosed are a novel tetrahydroisoquinoline compound, a method for preparing intermediates thereof, a pharmaceutical composition thereof and the use thereof. The tetrahydroisoquinoline compound of the present invention has a good inhibitory effect on phosphodiesterase (PDE4), and can be used in the prevention, treatment or auxiliary treatment of multiple diseases associated with the activity or expression of phosphodiesterase, especially PDE4-associated immune and inflammatory diseases, such as psoriasis and arthritis. (I)

A substituted indole -3 - acetic acid synthesis method (by machine translation)

The present invention provides a substituted indole - 3 - acetic acid synthesis method, comprises the following steps: (1) in order to replace the indole as the starting material, with the acylation reagent under the action of catalyst through the tutor - acylation to obtain the 1, 3 - diacetyl substituted indole; (2) intermediate 1, 3 - diacetyl substituted indole does not need refining, directly with the morpholine and sulfur by the Willgerodt - Kindler rearrangement reaction, the inorganic under the catalysis of alkali hydrolysis, acidified to obtain substituted indole - 3 - acetic acid. (by machine translation)

Compounds exhibiting thrombopoietin-like activities

The compounds of the invention are compounds represented by the following general formula (1): wherein E represents one selected from the group consisting of a methylidyne group and a nitrilo group, R1 represents one selected from the group consisting of optionally substituted aryl groups and optionally substituted heteroaryl groups, R2 represents one selected from the group consisting of a hydrogen atom and alkyl groups, W1 represents an amino acid residue, A represents one selected from the group consisting of a carbonyl group and a sulfonyl group, X1 represents one selected from the group consisting of optionally substituted alkylene groups and optionally substituted alkenylene groups, and p represents 0 or 1; and their pharmacologically acceptable salts, which exhibit thrombopoietin-like activity.