1913269-12-1 Usage
Description
KN-93 (phosphate) is a cell-permeable and reversible inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) that works by specifically blocking the association of calmodulin (CaM) with the kinase domain, thereby preventing the activation of CaMKII.
Used in Research Applications:
KN-93 (phosphate) is used as a research tool for investigating the role of CaMKII in various cellular processes such as neurotransmission, synaptic plasticity, and muscle contraction.
Used in Pharmaceutical Applications:
KN-93 (phosphate) is used as a potential therapeutic agent for treating neurological and cardiovascular diseases due to its ability to modulate CaMKII activity and downstream signaling pathways.
Used in Drug Development:
KN-93 (phosphate) is used as a lead compound in the development of new drugs targeting CaMKII for the treatment of various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1913269-12-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,9,1,3,2,6 and 9 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1913269-12:
(9*1)+(8*9)+(7*1)+(6*3)+(5*2)+(4*6)+(3*9)+(2*1)+(1*2)=171
171 % 10 = 1
So 1913269-12-1 is a valid CAS Registry Number.
1913269-12-1Relevant articles and documents
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II
Bruno, Claudio,Lentini, Giovanni,Catalano, Alessia,Carocci, Alessia,Lovece, Angelo,Di Mola, Antonia,Cavalluzzi, Maria Maddalena,Tortorella, Paolo,Loiodice, Fulvio,Iaccarino, Guido,Campiglia, Pietro,Novellino, Ettore,Franchini, Carlo
experimental part, p. 4193 - 4198 (2011/02/22)
Convenient synthetic routes to KN-93, N-(2-{[[(2E)-3-(4-chlorophenyl)prop- 2-enyl](methyl)amino]methyl}phenyl)-N-(2-hydroxyethyl)-4- methoxybenzenesulfonamide, a well-known Ca2+/calmoduline-dependent protein kinase II (CaMKII) inhibitor, are de
