1919868-77-1

Basic information

• Product Name: (R)-2-(2,5-difluorophenyl)pyrrolidine (R)-2-hydroxysuccinate
• Synonyms: (R)-2-(2,5-difluorophenyl)pyrrolidine (R)-2-hydroxysuccinate;(R)-2-(2,5-Difluorophenyl)pyrrolidine Malic acid
• CAS NO: 1919868-77-1
• Molecular Formula: C14H17F2NO5
• Molecular Weight: 317.29
• Mol File: 1919868-77-1.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Density: 1.389 at 20℃
• Vapor Pressure: 0.005Pa at 20℃
• CAS DataBase Reference: (R)-2-(2,5-difluorophenyl)pyrrolidine (R)-2-hydroxysuccinate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(2,5-difluorophenyl)pyrrolidine (R)-2-hydroxysuccinate(1919868-77-1)
• EPA Substance Registry System: (R)-2-(2,5-difluorophenyl)pyrrolidine (R)-2-hydroxysuccinate(1919868-77-1)

Safety Data

• Hazardous Substances Data: 1919868-77-1(Hazardous Substances Data)

Usage

General Description

The chemical (R)-2-(2,5-difluorophenyl)pyrrolidine (R)-2-hydroxysuccinate is a compound with a molecular structure that includes a pyrrolidine ring, a difluorophenyl group, and a hydroxysuccinate moiety. (R)-2-(2,5-difluorophenyl)pyrrolidine (R)-2-hydroxysuccinate is classified as a pyrrolidine derivative and can be used in organic synthesis and medicinal chemistry. It may have potential applications in pharmaceuticals and agrochemicals due to its unique structure and properties. The (R)-2-hydroxysuccinate group may also have implications for chiral catalysis and asymmetric synthesis. Further research and development of this compound could lead to its incorporation into various processes and products in the chemical industry.

Upstream product

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Downstream Products

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• 1223405-08-0 (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate 
• 1218935-59-1 (R)-(+)-2-(2,5-difluorophenyl)pyrrolidine 

Relevant articles and documents

Racemization method of larotinib intermediate

The invention discloses a racemization method of a larotinib intermediate, which comprises the following steps: in a solvent, heating (2S)-2-(2, 5-difluorophenyl)pyrrolidine(compound I, S-type I) or aracemic mixture mainly comprising S-type I, and convert

Synthesis method of (R)-2-(2, 5-difluorophenyl) pyrrolidine

The invention belongs to the technical field of chemical pharmacy, and relates to a synthetic method of (R)-2-(2, 5-difluorophenyl)pyrrolidine. The synthesis method comprises the following steps: (1) carrying out dehydration condensation reaction on a compound as shown in a formula 1 and a chiral induction reagent (R) tert-butylsulfinamide to obtain a compound as shown in a formula 2; (2) carrying out addition reaction on the compound in the formula 2 and a Grignard reagent to obtain a compound in a formula 3; (3) carrying out a reduction/cyclization reaction on the compound shown in the formula 3, trifluoroacetic acid and triethylsilane to obtain a compound shown in a formula 4; (4) splitting the compound shown in the formula 4 by (D)-malic acid to obtain the (R)-2-(2, 5-difluorophenyl) pyrrolidine*D malate compound with EE being greater than 98% shown in the formula 5; and (5) dissociating the compound in the formula 5 with a sodium hydroxide solution to obtain (R)-2-(2, 5-difluorophenyl) pyrrolidine. By utilizing the synthetic method of (R)-2-(2,5-difluorophenyl)pyrrolidine, the cost is low, the optical purity is high, the subsequent separation process is simplified, the raw materials are easy to obtain, the process conditions are mild, and the synthetic method is suitable for synthesizing (R)-2-(2, 5-difluorophenyl) pyrrolidine in large-scale production.

Preparation method of (R)-2-(2,5-difluorophenyl)-pyrrolidine

The invention discloses a preparation method of (R)-2-(2, 5-difluorophenyl)-pyrrolidine, and a preparation method of a compound represented by a formula III, wherein the method comprises the followingstep: in an organic solvent, carrying out a reaction defined in the specification on a compound represented by a formula II and a compound represented by a formula I to obtain a compound representedby the formula III at a high yield and a high ee value. The preparation method is simple in reaction condition, convenient to operate, low in cost and high in industrial value.