19218-94-1Relevant articles and documents
Contra-thermodynamic Olefin Isomerization by Chain-Walking Hydroboration and Dehydroboration
Bloomer, Brandon,Butcher, Trevor W.,Ciccia, Nicodemo R.,Conk, Richard J.,Hanna, Steven,Hartwig, John F.
supporting information, p. 1005 - 1010 (2022/02/10)
We report a dehydroboration process that can be coupled with chain-walking hydroboration to create a one-pot, contra-thermodynamic, short-or long-range isomerization of internal olefins to terminal olefins. This dehydroboration occurs by a sequence comprising activation with a nucleophile, iodination, and base-promoted elimination. The isomerization proceeds at room temperature without the need for a fluoride base, and the substrate scope of this isomerization is expanded over those of previous isomerizations we have reported with silanes.
Synthesis of all the six components of the female-produced contact sex pheromone of the German cockroach, Blattella germanica (L.)
Mori, Kenji
, p. 4060 - 4071 (2008/09/20)
All of the following six components of the female sex pheromone of the German cockroach, Blattella germanica (L.) were synthesized: (3S,11S)-3,11-dimethyl-2-nonacosanone (1), its 29-hydroxy derivative 2, its 29-oxo derivative 3, (3S,11S)-3,11-dimethyl-2-heptacosanone (4), its 27-hydroxy derivative 5, and its 27-oxo derivative 6. Both the enantiomers of citronellal were employed as the chiral sources and Wacker oxidation was employed for the introduction of the carbonyl group at C-2.
Novel Biodegradable Pyridinium Amphiphiles for Gene Delivery
Pijper, Dirk,Bulten, Erna,Smisterova, Jarmila,Wagenaar, Anno,Hoekstra, Dick,Engberts, Jan B. F. N.,Hulst, Ron
, p. 4406 - 4412 (2007/10/03)
Biodegradable synthetic cationic pyridinium-based amphiphiles (SAINTs) prove to be promising non-viral carrier systems for delivery of DNA into eukaryotic cells. Six novel SAINTs were synthesised from 3,5-pyridinedicarboxylic acid as starting material, with two ester groups as linkers between the cationic headgroup and the hydrophobic tails. The vesicle-forming properties of the amphiphiles were studied by differential scanning calorimetry and transmission electron microscopy, whereas the hydrolysis of the diesters in water was investigated by NMR spectroscopy. Finally, the transfection potential and cytotoxicity were determined on COS-7 and HepG-2 cells in culture. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.