192332-47-1

Basic information

• Product Name: para-methoxy-benzamidoxime
• CAS NO: 192332-47-1
• Molecular Weight: 166.18
• Mol File: 192332-47-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: para-methoxy-benzamidoxime(CAS DataBase Reference)
• NIST Chemistry Reference: para-methoxy-benzamidoxime(192332-47-1)
• EPA Substance Registry System: para-methoxy-benzamidoxime(192332-47-1)

Safety Data

• Hazardous Substances Data: 192332-47-1(Hazardous Substances Data)

Upstream product

• 874-90-8 4-methoxybenzonitrile 

Downstream Products

• 40019-25-8 ethyl 3-(4-methoxyphenyl)-1,2,4-oxadiazole-5-carboxylate 
• 102151-70-2 4-Carbomethoxy-2-(p-methoxyphenyl)imidazole 
• 108-95-2 phenol 
• 5311-71-7 methyl 4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl ether 
• 949-02-0 C₁₀H₁₂N₂O₃ 

Relevant articles and documents

Design, synthesis, and biological evaluation of novel oxadiazole- and thiazole-based histamine H3R ligands

Histamine H3 receptor (H3R) is largely expressed in the CNS and modulation of the H3R function can affect histamine synthesis and liberation, and modulate the release of many other neurotransmitters. Targeting H3R with antagonists/inverse agonists may have therapeutic applications in neurodegenerative disorders, gastrointestinal and inflammatory diseases. This prompted us to design and synthesize azole-based H3R ligands, i.e. having oxadiazole- or thiazole-based core structures. While ligands of oxadiazole scaffold were almost inactive, thiazole-based ligands were very potent and several exhibited binding affinities in a nanomolar concentration range. Ligands combining 4-cyanophenyl moiety as arbitrary region, para-xylene or piperidine carbamoyl linkers, and/or pyrrolidine or piperidine basic heads were found to be the most active within this series of thiazole-based H3R ligands. The most active ligands were in silico screened for ADMET properties and drug-likeness. They fulfilled Lipinski's and Veber's rules and exhibited potential activities for oral administration, blood–brain barrier penetration, low hepatotoxicity, combined with an overall good toxicity profile.

Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, Ar3, A, B and D are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Phenoxy- and phenoxyalkyl-piperidines as antiviral agents

Compounds of the formula STR1 wherein R1 is selected from STR2 Y is a bond or lower alkylene; R2 and R3 are independently hydrogen, lower-alkyl or halogen; R4 is STR3 R5 is hydrogen, lower-alkyl or halogen; R6 is hydrogen, lower-alkyl or halogen; R7 is hydrogen or lower-alkyl; R8 is hydrogen, lower-alkyl, or trifluoromethyl; R9 is lower-alkyl; R10 is lower-alkyl, trifluoromethyl or difluoromethyl; or pharmaceutically acceptable acid addition salts thereof are useful as antiviral agents.