19276-01-8Relevant articles and documents
Synthesis of α-Aminocyclopropyl Ketones and 2-Substituted Benzoimidazoles from 2-Hydroxycyclobutanones and Aryl Amines
Serusi, Lorenzo,Soddu, Francesco,Cuccu, Federico,Peretti, Giuseppe,Luridiana, Alberto,Secci, Francesco,Caboni, Pierluigi,Aitken, David J.,Frongia, Angelo
, p. 4159 - 4163 (2020)
We have developed one-step protocols for the preparation of a large selection of α-aminocyclopropyl ketones or benzo[d]imidazoles, by reacting 2-substituted-2-hydroxycyclobutanones with aryl amines or o-phenylenediamines, respectively. In most case the reactions proceed at room temperature and are catalyst-free. The formation of benzo[d]imidazoles is rationalized in terms of an unusual ring-closure/ring-fission process followed by aromatization. (Figure presented.).
Reaction of 2-chloromethylbenzimidazoles with acetylacetone and benzoylacetone. Basic breakdown of β-diketones
Popov
, p. 918 - 922 (2007/10/03)
Base treatment of the products of alkylalion of β-diketones by 2-chloromethylbenzimidazole under phase transfer catalysis (PTC) conditions causes loss of the acetyl group and formation of methylethyl- or ethylphenyl ketones. 1997 Plenum Publishing Corpora