192800-77-4

Basic information

• Product Name: (S) 3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRYL CHLORIDE
• Synonyms: (S) 3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRYL CHLORIDE;(S)-Tetrahydro-α-(1-methylethyl)-2-oxo-;(S)-Tetrahydro-α-(1-Methylethyl)-2-oxo-1(2H)-pyriMidineacetyl Chloride
• CAS NO: 192800-77-4
• Molecular Formula: C₉H₁₅ClN₂O₂
• Molecular Weight: 218.682
• Product Categories: Amino Acids & Derivatives;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals
• Mol File: 192800-77-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Solubility: Acetone, Chloroform
• CAS DataBase Reference: (S) 3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S) 3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRYL CHLORIDE(192800-77-4)
• EPA Substance Registry System: (S) 3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRYL CHLORIDE(192800-77-4)

Safety Data

• Hazardous Substances Data: 192800-77-4(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Upstream product

• 192725-50-1 (S)-tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetic acid 
• 126147-70-4 (2S)-3-Methyl-2-(phenoxycarbonyl)aminobutyric acid 
• 72-18-4 L-valine 

Downstream Products

• 192726-04-8 (2S,3S,5S)-2-N,N-dibenzylamino-3-hydroxy-5-(2S-(2-oxotetrahydropyrimidin-2-yl)-3-methylbutanoyl)amino-1,6-diphenylhexane 
• 192726-06-0 (2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(1-tetrahydro-pyrimid-2-onyl)-3-methylbutanoyl)amino-1,6-diphenylhexane (S)-pyroglutamic acid salt 
• 192725-17-0 lopinavir 
• 192726-05-9 (2S,3S,5S)-2-amino-3-hydroxy-5-(2S-(2-oxotetrahydropyrimidin-2-yl)-3-methylbutanoyl)amino-1,6-diphenylhexane 

Relevant articles and documents

NOVEL POLYMORPHS OF LOPINAVIR

The present invention provides a novel cyclohexane solvate form of lopinavir, and a process for its preparation thereof. The present invention also provides a novel desolvated crystalline form of lopinavir, process for its preparation and to pharmaceutical composition containing it. Thus, for example, lopinavir cyclohexane solvate was heated at 100° C. for 10 hours to give lopinavir desolvated crystalline form H1.

A PROCESS FOR THE SYNTHESIS OF 2-AMINO-5-PROTECTED AMINO-3-HYDROXY-1, 6-DIPHENYLHEXANE OR A SALT THEREOF - AN INTERMEDIATE FOR ANTIVIRAL DRUGS

The present invention relates to an improved process for preparing 2-amino-5-protected-amino-3-hydroxy-1,6-diphenylhexane compounds or acid addition salts thereof, which can be useful intermediates for preparing compounds with antiviral activity. The present invention further provides a process for preparing HIV protease inhibitors, lopinavir and ritonavir.

Retroviral protease inhibiting compounds

A compound comprising a substituent of the formula (II) is disclosed as an HIV protease inhibitor. Intermediates for making such compounds and processes for making such intermediates are also disclosed.