19294-04-3Relevant articles and documents
Distinct structures of inorganic-organic supramolecular assemblies based on discrete metallocyclic complexes incorporating flexible imidazole ligands: Syntheses, crystal structures and properties
Yang, Li,Chang, Guanjun,Luo, Liang,Ding, Feng,You, Jingsong
, p. 307 - 314 (2013)
Three new interesting discrete dinuclear metallocyclic complexes, namely, {[Pd2(1)4](NO3)4· 2DMSO· 2H2O}n (4), [Pd2(2) 2Br4]n (5), and {[Pd2(3) 2Cl4]·4DMSO}n (6) have been successfully synthesized by the reaction of flexible exo-bidentate imidazole-containing ligands 1, 3-bis(imidazol-1-ylmethyl)benzene (1), 1, 3-bis(imidazol-1-ylmethyl)- 5-methylbenzene (2), and 2, 6-bis(imidazol-1-ylmethyl)-4-tert-butyl-phenol (3) with corresponding palladium salts. All these complexes were characterized by NMR spectroscopy in combination with elemental analysis, powder X-ray diffraction (PXRD), single-crystal X-ray diffraction, and thermal gravimetric analysis (TGA), respectively. Though all three complexes involve the similar supramolecular building blocks [2+2] metallocyclic units, under the inducement effect of the organic ligands, compounds 4-6 exhibit delicate geometric diversification of the resulting high-dimensional inorganic-organic supramolecular assemblies (e.g., [4+2] lantern-like cage structure, 1D channel, and 2D undulating framework, respectively). Furthermore, these results demonstrate that the secondary interactions such as intermolecular π ··· π stacking interactions and hydrogen bonds could play important roles in the aspect of linking low-dimensional entities into high-dimensional supramolecular frameworks.
Self-assembly from metal-organic vesicles to globular networks: Metallogel-mediated phenylation of indole with phenyl boronic acid
Yang, Li,Luo, Liang,Zhang, Shuai,Su, Xiaoyu,Lan, Jingbo,Chen, Chi-Tien,You, Jingsong
supporting information; scheme or table, p. 3938 - 3940 (2010/07/14)
Self-assembly of the conformationally flexible bismethylimidazolyl ligands with Pd(OAc)2 is described. Depending on whether the ligands provide the hydrogen bonding donor, a switching of metal-organic vesicles to globular networks gelating solvents is achieved. The metallogels exhibit catalytic activity for the cross-coupling of indole with phenyl boronic acid.
Process for the Preparation of 2,2'-[5-(1H-1,2,4-Triazole-1-Ylmethyl) -1,3-Phenylene] Di (2-Methylpropionitrile)
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Page/Page column 5, (2008/12/08)
The present invention discloses a process for the preparation of Anastrozole of the formula I in high purity and in high yield. 3,5-bis(halomethyl)toluene is prepared by reacting mesitylene with N-halosuccinimide in the presence of light or dibenzoyl peroxide or azobis isobutyronitrile as a catalyst and in a chlorinated solvent. 3,5-bis(halomethyl)toluene is cyanated with metal cyanide in the presence of a catalyst and in water, organic solvent or mixture thereof at temperature of 40 to 60° C. to obtain 2,2′-(5-methyl-1,3 phenylene)diacetonitrile which is further methylated with iodomethane in the presence of base and an organic solvent at temperature of 0 to 15° C. to obtain 2,2′-(5-methyl-1,3-phenylene)di(2-methyl-propiononitrile). The product obtained is treated with N-halosuccinimide in the presence of a catalyst and in a chlorinated solvent at temperature of 60 to 100° C. to obtain 2,2′-(5-halomethyl-1,3-phenylene)di(2-methyl propionitrile) which was further treated with potassium or sodium salt 1,2,4-triazole at temperature of 20 to 50° C. in dimethyl formamide to obtain crude 2,2′-[5-(1H-1,2,4-triazole-1-ylmethyl)-1,3-phenylene]di(2-methyl-propionitrile). The crude product is purified by column chromatography using a stationary phase and a mobile phase followed by recrystallization with a solvent or mixture of solvents to obtain highly pure Anastrozole.
