193687-88-6

Basic information

• Product Name: 1-Butanone, 1-(2-hydroxy-4-methoxyphenyl)-3-methyl-
• CAS NO: 193687-88-6
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Mol File: 193687-88-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-Butanone, 1-(2-hydroxy-4-methoxyphenyl)-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butanone, 1-(2-hydroxy-4-methoxyphenyl)-3-methyl-(193687-88-6)
• EPA Substance Registry System: 1-Butanone, 1-(2-hydroxy-4-methoxyphenyl)-3-methyl-(193687-88-6)

Safety Data

• Hazardous Substances Data: 193687-88-6(Hazardous Substances Data)

Upstream product

• 503-74-2 3-methylbutyric acid 
• 150-19-6 O-methylresorcine 
• 89232-58-6 O-(3-methoxyphenyl)hydroxylamine 
• 10365-98-7 3-methoxyphenylboronic acid 
• 816-66-0 4-methyl-2-oxopentanoic acid 
• 108-12-3 isopentanoyl chloride 
• 590-86-3 isovaleraldehyde 
• 108-46-3 recorcinol 
• 462610-98-6 1-(2-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)ethan-1-one 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 462611-02-5 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-3-methyl-butan-1-one 
• 15116-14-0 2,4-dihydroxyphenyl isobutyl ketone 
• 77-78-1 dimethyl sulfate 
• 20321-73-7 7-methoxy-2,2-dimethyl-4-chromanone 

Downstream Products

• 193687-91-1 5-methoxy-2-(3-methyl-1-hydroxybutyl)phenol 
• 179630-64-9 5-Methoxy-2-(3-methyl-1-propylsulfanyl-butyl)-phenol 

Relevant articles and documents

RhIII-Catalyzed Decarboxylative o-Acylation of Arenes Bearing an Oxidizing Directing Group

Here in we report, rhodium(III)-catalyzed decarboxylative acylation of arenes using α-oxocarboxylic acids as acyl surrogate. In this strategy, O–NHAc group act as an autocleavable oxidizing directing group (ODGauto), thus giving rise to ortho-acylated phenols in moderate to good yields. Mechanistic studies provided strong support for a kinetically relevant C–H bond activation. According to the best of our knowledge, this is the first report of Rhodium catalyzed decarboxylative acylation.

Synthesis of 2-acylphenol and flavene derivatives from the ruthenium-catalyzed oxidative c-h acylation of phenols with aldehydes

The cationic ruthenium hydride complex [(C6H6)(PCy3)(CO)RuH]+BF4- has been found to be an effective catalyst for the oxidative C-H coupling reaction of phenols with aldehydes to give 2-acylphenol compounds. The coupling of phenols with α,β-unsaturated aldehydes selectively gives the flavene derivatives. The catalytic method mediates direct oxidative C-H coupling of phenol and aldehyde substrates without using any metal oxidants or forming wasteful byproducts. A cationic ruthenium hydride complex catalyzes the oxidative C-H coupling of phenols with aldehydes to form 2-acylphenol and flavene derivatives.

Synthesis and biological evaluation of some novel 4H-benzopyran-4-one derivatives as nonsteroidal antiestrogens

The preparation and characterization of some novel 2- and 3-substituted-7-methoxy-4H-1-benzopyran-4-one are presented. The synthesized compounds were evaluated for their uterotrophic, antiuterotrophic and antiimplantation activities in mature female albino rats. 3-Benzyl-7-methoxy-4H-1-benzopyran-4-one (14) showed the highest uterotrophic activity (87%) based on dry uterine weight gain. The antifertility activity, as assessed by the post-coital antiimplantation activity test, was of weak potency for most compounds (14-29%). Among the products, the 2-(4′-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one (19) exhibited the highest antiestrogenic activity of 65%. It also elicited 31% of the uterotrophic activity of estradiol.