193896-38-7

Basic information

• Product Name: C₃₃H₄₇N₇O₆S
• CAS NO: 193896-38-7
• Molecular Weight: 669.845
• Mol File: 193896-38-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₃H₄₇N₇O₆S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₄₇N₇O₆S(193896-38-7)
• EPA Substance Registry System: C₃₃H₄₇N₇O₆S(193896-38-7)

Safety Data

• Hazardous Substances Data: 193896-38-7(Hazardous Substances Data)

Upstream product

• 13836-37-8 Boc-Arg(Tos)-OH 
• 63-45-6 primaquine diphosphate 

Downstream Products

• 193896-43-4 C₂₈H₃₉N₇O₄S 

Relevant articles and documents

Synthesis and in vitro evaluation of potential antichagasic dipeptide prodrugs of primaquine

American trypanosomiasis (Chagas' disease) is an endemic parasitic disease afflicting more than 20 million people in Latin America. Currently, therapy is unsatisfactory and only two drugs are available. Primaquine, an antimalarial drug, has trypanocidal activity. Dipeptide derivatives of primaquine. Phe-Arg-PQ, Lys-Arg-PQ, and Phe-Ala-PQ, were synthesized. The choice of the peptides was based on the primary specificity of cruzipain, the major cysteine proteinase from T. cruzi. The prodrugs obtained were tested on the LLC-MK2 cell culture infected with trypomastigotes forms of T. cruzi. Phe-Arg-PQ, Lys-Arg-PQ, and Phe-Ala-PQ were active in all stages.