193904-48-2

Basic information

• Product Name: Aziridine, 1-[(4-nitrophenyl)sulfonyl]-2-(phenylmethyl)-
• Synonyms: 2-benzyl-1-(p-nitro-benzenesulfonyl)aziridine;Aziridine,1-[(4-nitrophenyl)sulfonyl]-2-(phenylmethyl);N-(4-nitrobenzenesulfonyl)-2-benzylaziridine
• CAS NO: 193904-48-2
• Molecular Formula: C15H14N2O4S
• Molecular Weight: 318.353
• Mol File: 193904-48-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Aziridine, 1-[(4-nitrophenyl)sulfonyl]-2-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Aziridine, 1-[(4-nitrophenyl)sulfonyl]-2-(phenylmethyl)-(193904-48-2)
• EPA Substance Registry System: Aziridine, 1-[(4-nitrophenyl)sulfonyl]-2-(phenylmethyl)-(193904-48-2)

Safety Data

• Hazardous Substances Data: 193904-48-2(Hazardous Substances Data)

Upstream product

• 300-57-2 allylbenzene 
• 149552-43-2 [N-(nosyl)imino]phenyliodinane 
• 73901-01-6 p-nitrobenzenesulfonyl azide 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 149552-43-2 [N-(p-nitrophenylsulfonyl)imino]phenyliodinane 

Downstream Products

• 339570-27-3 N-{1-[(1-naphthalen-1-yl-ethylamino)-methyl]-2-phenyl-ethyl}-4-nitro-benzenesulfonamide 
• 1026647-17-5 N¹-(1-naphthalen-1-yl-ethyl)-3-phenyl-propane-1,2-diamine 
• 732237-56-8 3-phenyl-N¹-(1-phenyl-ethyl)-propane-1,2-diamine 

Relevant articles and documents

[FeIII(F20-tpp)Cl] Is an effective catalyst for nitrene transfer reactions and animation of saturated hydrocarbons with sulfonyl and aryl azides as nitrogen source under thermal and microwave-assisted conditions

[FeIII(F20-tpp)Cl] (F20tpp = meso- tetrakis(pentafluorophenyl)porphyrinato dianion) is an effective catalyst for imido/nitrene insertion reactions using sulfonyl and aryl azides as nitrogen source. Under thermal conditions, aziridination of aryl and alkyl alkenes (16 examples, 60-95% yields), sulfimidation of sulfides (11 examples, 76-96% yields), allylic amidation/amination of α-methylstyrenes (15 examples, 68-83% yields), and amination of saturated C-H bonds including that of cycloalkanes and adamantane (eight examples, 64-80% yields) can be accomplished by using 2 mol % [FeIII(F20- tpp)Cl] as catalyst. Under microwave irradiation conditions, the reaction time of aziridination (four examples), allylic amination (five examples), sulfimidation (two examples), and amination of saturated C-H bonds (three examples) can be reduced by up to 16fold (24-48 versus 1.5-6 h) without significantly affecting the product yield and substrate conversion.

N1-arylsulfonyl-N2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines as novel calcimimetics acting on the calcium sensing receptor

The synthesis and calcimimetic properties of N1-arylsulfonyl-N2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines are described. The most active compound of the series (3n, used at 10 μM) produced 974±11% of the maximal stimulation of [3H]IP production obtained by 10 mM Ca2+ in CHO cells expressing the calcium sensing receptor (CaSR). This calcimimetic activity was due to a specific interaction of this compound with the CaSR. (C) 2000 Elsevier Science Ltd.