19547-38-7Relevant articles and documents
Synthesis, DNA-binding and photocleavage of "light switch" complexes [Ru(bpy)2(pyip)]2+ and [Ru(phen) 2(pyip)]2+
Liu, Xue-Wen,Shen, You-Ming,Lu, Ji-Lin,Chen, Yuan-Dao,Li, Lin,Zhang, Da-Shun
, p. 522 - 527 (2010)
Two novel Ru(II) complexes [Ru(bpy)2(pyip)]2+ 1 and [Ru(phen)2(pyip)]2+ 2 (bpy = 2,2′-bipyridine; phen = 1,10-phenanthroline; pyip = 2-(pyridine-2-yl)imidazo-[4,5-f][1,10]- phenanthroline), have been synthesized and characterized by elemental analysis, ES-MS, 1H NMR, UV-Vis. The DNA-binding behaviors of both complexes were studied by spectroscopic methods and viscosity measurements. The results indicate that the two complexes can bind to CT-DNA in an intercalative mode, and also show that these two Ru(II) complexes can promote the photocleavage of pBR322 DNA. In addition, In the presence of Co2+, the emission of DNA-[Ru(L)2pyip]2+ can be quenched, which exhibited the DNA "light switch" properties.
In vitro and in vivo biological effects of novel arylimidamide derivatives against Trypanosoma cruzi
Timm, Bruno Lisboa,Da Silva, Patricía Bernadino,Batista, Marcos Meuser,Da Silva, Francisca Hildemagna Guedes,Da Silva, Cristiane Fran?a,Tidwell, Richard R.,Patrick, Donald A.,Jones, Susan Kilgore,Bakunov, Stanislav A.,Bakunova, Svetlana M.,Soeiro, Maria De Nazaré C.
, p. 3720 - 3726 (2014)
Chagas disease (CD), a neglected tropical disease caused by Trypanosoma cruzi, remains a serious public health problem in several Latin American countries. The available chemotherapies for CD have limited efficacy and exhibit undesirable side effects. Aro
Cyanoamidines. I. Synthesis and vasodilatory activity of N-substituted heteroaromatic cyanoamidines
Nakajima,Izawa,Kashiwabara,Nakajima,Munezuka
, p. 2475 - 2482 (1994)
Various heteroaromatic cyanoamidines were synthesized starting from nitriles via cyanoimidates or from amides via thioamides. The compounds were tested for inhibitory effect on the 40 mM K+-induced contraction of rat aorta strips and selected compounds were also evaluated for antagonism of the norepinephrine-induced contraction. Most of the cyanoamidines showed vasodilatory activities. Potent vasoactive compounds were also examined for stimulation of the 86Rb+ efflux to determine their potassium channel opening actions. Maximum potency was displayed by N-cyano-N'-(2-nitroxyethyl)-3-pyridinecarboxamidine (3h). The methanesulfonate of 3h, which was designated as KRN2391, has been selected for further development as an antianginal agent.
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Watanabe,Kidokoro
, p. 67,70 (1975)
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New iridium complex as high-efficiency red phosphorescent emitter in polymer light-emitting devices
Liang, Bo,Jiang, Changyun,Chen, Zhao,Zhang, Xiuju,Shi, Huahong,Cao, Yong
, p. 1281 - 1286 (2006)
A new heteroleptic iridium complex Ir(1-piq)2pt with 1-phenylisoquinoline and 3-(pyridin-2′-yl)-1H-1,2,4-triazole was synthesized and characterized. The complex was incorporated into phosphorescent polymer light-emitting devices using polyhedral oligomeric silsesquioxane- terminated polyfluorene (PFO-poss) as a host polymer doped with 30% of electron transport materials 2-(4-biphenylyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole (PBD). Red electrophosphorescence was observed with a peak emission at 605 nm. The highest-efficiency polymer light-emitting diode was achieved with PFO-poss doped with 2% Ir(1-piq)2pt. An external quantum efficiency of 10.4% and a luminous efficiency of 9.4 cd A-1 were obtained at 10.8 mA cm-2. These values were found to be 7.67% and 5.99 cd A-1 at 100 mA cm-2.
Self-assembled polymetallic square grids ([2 × 2] M4, [3 × 3] M9) and trigonal bipyramidal clusters (M5) - Structural and magnetic properties
Dawe, Louise N.,Abedin, Tareque S. M.,Kelly, Timothy L.,Thompson, Laurence K.,Miller, David O.,Zhao, Liang,Wilson, Claire,Leech, Michael A.,Howard, Judith A. K.
, p. 2645 - 2659 (2006)
New self-assembled grids and clusters are reported, with square [2 × 2] M4 (M = Mn(ii)4, Cu(ii)4), trigonal-bipyramidal Mn(ii)5, and square [3 × 3] M9 (M = Mn(ii), Cu(ii)) examples. These are based on a series of ditopic and tritopic hydrazone ligands involving pyridine, pyrimidine and imidazole end groups. In all cases the metal centres are bridged by hydrazone oxygen atoms with large (>125°) bridge angles, leading to antiferromagnetic exchange for all the Mn systems (J = -2 to -5 cm-1), which results in S = 0 (Mn4), and S = 5/2 (Mn5, Mn9) ground states. The copper systems have a 90° alternation of the Jahn-Teller axes within the Cu4 and Cu8 grid rings (Cu9), which leads to magnetic orbital orthogonality, and dominant ferromagnetic coupling. For the Cu9 grid antiferromagnetic exchange between the ring and the central copper leads to a S = 7/2 ground state, while for the Cu4 grids S = 4/2 ground states are observed. The magnetic data have been treated using isotropic exchange models in the cases of the Cu4 and Cu9 grids, and the Mn5 clusters. However due to the enormity of a fully isotropic calculation a simplified model is used for the Mn9 grid, in which the outer Mn8 ring is treated as the equivalent of an isolated magnetic chain, with no coupling to the central metal ion. The Royal Society of Chemistry 2006.
Syntheses, characterization, and X-ray crystal structures of two cis-dioxovanadium(V) complexes of pyrazole-derived, Schiff-base ligands
Roy, Somnath,Mandal, Tarak Nath,Das, Kinsuk,Butcher, Ray J.,Rheingold, Arnold L.,Kumar Kar, Susanta
, p. 2146 - 2157 (2010)
Two mononuclear cis-dioxovanadium(V) complexes of pyrazole-derived, Schiff-base ligands have been synthesized and characterized. Single crystal X-ray analyses were performed with N '-[(3-methyl-1H-pyrazole-5-yl)carbonyl] pyridine-2-carbohadrazonamido cis-dioxovanadium(V), {[VO2(PzOAP)] H2O} (1), and 5-methyl-N-[(1E)-1-(pyridin-2-yl)ethylidene]-1H- pyrazole-3-carbohydrazonate cis-dioxovanadium(V), {[VO2(PzCAP)]} (2). Both complexes crystallize in monoclinic crystal systems with different space groups. Complex 1 crystallizes in the space group P21/c, 2 in space group C2/C. In each complex, the vanadium sits within a distorted square pyramidal geometry with an N2O3 chromophore. The parameters of the complexes (0.33 for 1, 0.22 for 2) support their square pyramidal geometry. The interesting finding in the work is that the alkoxide oxygen, imino nitrogen, and pyridine nitrogen take part in the coordination process leaving the pyrazole rings inactive in coordination.
An orthogonal ferromagnetically coupled tetracopper(II) 2 × 2 homoleptic grid supported by -O4 bridges and its DFT study
Roy, Somnath,Mandal, Tarak Nath,Barik, Anil Kumar,Pal, Sachindranath,Butcher, Ray J.,El Fallah, Mohamed Salah,Tercero, Javier,Kar, Susanta Kumar
, p. 1229 - 1234 (2007)
A pyrazole based ditopic ligand (PzOAP), prepared by the reaction between 5-methylpyrazole-3-carbohydrazide and methyl ester of imino picolinic acid, reacts with Cu(NO3)2·6H2O to form a self-assembled, ferromagnetically coupled, alkoxide bridged tetranuclear homoleptic Cu(ii) square grid-complex [Cu4(PzOAP)4(NO 3)2] (NO3)2·4H2O (1) with a central Cu4[-O4] core, involving four ligand molecules. In the Cu4[-O4] core, out of four copper centers, two copper centers are penta-coordinated and the remaining two are hexa-coordinated. In each case of hexa-coordination, the sixth position is occupied by the nitrate ion. The complex 1 has been characterized structurally and magnetically. Although Cu-O-Cu bridge angles are too large (138-141°) and Cu-Cu distances are short (4.043-4.131 A), suitable for propagation of expected antiferromagnetic exchange interactions within the grid, yet intramolecular ferromagnetic exchange (J = 5.38 cm-1) is present with S = 4/2 magnetic ground state. This ferromagnetic interaction is quite obvious from the bridging connections (dx2-y2) lying almost orthogonally between the metal centers. The exchange pathways parameters have been evaluated from density functional calculations. The Royal Society of Chemistry 2007.
In vitro and in vivo trypanosomicidal action of novel arylimidamides against trypanosoma cruzi
Guedes-Da-Silva,Batista,Meuser,Demarque,Fulco,Araújo,Da Silva,Da Silva,Patrick,Bakunova,Bakunov,Tidwell,Oliveira,Britto,Moreira,Soeiro
, p. 2425 - 2434 (2016)
Arylimidamides (AIAs) have been shown to have considerable biological activity against intracellular pathogens, including Trypanosoma cruzi, which causes Chagas disease. In the present study, the activities of 12 novel bis-AIAs and 2 mono-AIAs against dif
New palladium(ii) complexes with 3-(2-pyridyl)-5-alkyl-1,2,4-triazole ligands as recyclable C-C coupling catalysts
Zakharchenko, Borys V.,Khomenko, Dmytro M.,Doroshchuk, Roman O.,Raspertova, Ilona V.,Starova, Viktoriia S.,Trachevsky, Volodymyr V.,Shova, Sergiu,Severynovska, Olga V.,Martins, Luísa M. D. R. S.,Pombeiro, Armando J. L.,Arion, Vladimir B.,Lampeka, Rostyslav D.
, p. 10973 - 10984 (2019)
A series of palladium(ii) complexes with 3-(2-pyridyl)-5R-1,2,4-triazoles Pd(LR)2 (R = ethyl (4a), n-propyl (4b), i-propyl (4c) and t-butyl (4d)) have been synthesised and characterised by NMR, IR, UV-vis spectroscopy, ESI and MALDI-
Enantioselective Synthesis of N-Benzylic Heterocycles: A Nickel and Photoredox Dual Catalysis Approach
Pezzetta, Cristofer,Bonifazi, Davide,Davidson, Robert W. M.
supporting information, p. 8957 - 8961 (2019/11/11)
Reported herein is a dual nickel- and photoredox-catalyzed modular approach for the preparation of enantioenriched N-benzylic heterocycles. α-Heterocyclic carboxylic acids, easily obtainable from common commercial material, are reported as suitable substrates for a decarboxylative strategy in conjunction with a chiral pyridine-oxazoline (PyOx) ligand, providing quick access to enantioenriched drug-like products. The presence of a directing group on the heterocyclic moiety is shown to be beneficial, affording improved stereoselectivity in a number of cases.
PLATINUM COMPOUNDS FOR BINDING GUANINE QUADRAPLEXES
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Page/Page column 36; 40, (2019/06/05)
Compounds are described and characterized that bind guanine quadruplexes of DNA or RNA. Binding data and inhibition of growth data of five cancer cell lines are presented.
