195877-90-8

Basic information

• Product Name: 3-(1-Cbz-4-piperidyl)-2-(Boc-aMino)propanoic Acid
• Synonyms: 3-(1-Cbz-4-piperidyl)-2-(Boc-aMino)propanoic Acid;a-(Boc-amino)-1-Cbz-4-piperidinepropanoic acid;3-(1-((Benzyloxy)carbonyl)piperidin-4-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid
• CAS NO: 195877-90-8
• Molecular Formula: C₂₁H₃₀N₂O₆
• Molecular Weight: 406.4727
• Mol File: 195877-90-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(1-Cbz-4-piperidyl)-2-(Boc-aMino)propanoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-Cbz-4-piperidyl)-2-(Boc-aMino)propanoic Acid(195877-90-8)
• EPA Substance Registry System: 3-(1-Cbz-4-piperidyl)-2-(Boc-aMino)propanoic Acid(195877-90-8)

Safety Data

• Hazardous Substances Data: 195877-90-8(Hazardous Substances Data)

Usage

Description

3-(1-Cbz-4-piperidyl)-2-(Boc-aMino)propanoic Acid is a chemical compound with a complex structure, featuring a benzyloxycarbonyl (Cbz) group attached to a piperidine ring and a tert-butoxycarbonyl (Boc) group attached to an amino group. 3-(1-Cbz-4-piperidyl)-2-(Boc-aMino)propanoic Acid is characterized by its ability to act as a transition state inhibitor, which is significant in the context of coagulation enzymes.

Uses

Used in Pharmaceutical Industry:
3-(1-Cbz-4-piperidyl)-2-(Boc-aMino)propanoic Acid is used as a transition state inhibitor for coagulation enzymes, playing a crucial role in the development of therapeutic agents targeting blood clotting disorders. Its ability to inhibit the activity of coagulation enzymes can help in the treatment and prevention of conditions such as deep vein thrombosis, pulmonary embolism, and other clot-related diseases.
Additionally, due to its structural properties, 3-(1-Cbz-4-piperidyl)-2-(Boc-aMino)propanoic Acid may also be utilized in the synthesis of other bioactive compounds, potentially expanding its applications in the pharmaceutical industry for various therapeutic purposes.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 195877-36-2 2-acetylamino-2-pyridin-4-ylmethyl-malonic acid monoethyl ester 
• 195877-37-3 2-acetylamino-3-piperidin-4-yl-propionic acid ethyl ester 
• 89662-46-4 ethyl (D, L)-2-acetamido-3-(pyridin-4-yl)propanoate 
• 89662-45-3 diethyl 2-(acetylamino)-2-(4-pyridinylmethyl)-malonate 
• 10445-91-7 4-(Chloromethyl)pyridine 

Downstream Products

• 1021943-36-1 benzyl 4-{2-[(tert-butoxycarbonyl)amino]-3-(cyclopentyloxy)-3-oxopropyl}piperidine-1-carboxylate 
• 195878-47-8 4-(2-{[(S)-1-((R)-3-Cyclohexyl-2-ethanesulfonylamino-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-oxo-3-thiazol-2-yl-propyl)-piperidine-1-carboxylic acid benzyl ester 
• 195877-92-0 4-(2-tert-butoxycarbonylamino-3-oxo-3-thiazol-2-yl-propyl)-piperidine-1-carboxylic acid benzyl ester 
• 195877-93-1 4-(2-amino-3-oxo-3-thiazol-2-yl-propyl)-piperidine-1-carboxylic acid benzyl ester 
• 195877-91-9 4-[2-tert-butoxycarbonylamino-2-(methoxy-methyl-carbamoyl)-ethyl]-piperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Solution-phase and solid-phase synthesis of novel transition state inhibitors of coagulation enzymes incorporating a piperidinyl moiety

2-Amino-3-piperidin-4-yl-propionic acid containing peptidomimetics are potent protease inhibitors when combined with an appropriate keto-thiazole or keto-carboxylic acid moiety. A novel P1 residue in factor Xa and thrombin inhibitors has been found resulting in IC50 values as low as 0.048 μM, a factor of ten more potent than Argatroban. Starting with non-chiral synthetic routes, a new stereospecific route was developed as well as a new solid- phase method.