195985-82-1

Basic information

• Product Name: (3R)-7-Cyano-1,2,3,5-tetrahydro-N,N-dimethyl-3-(phenylmethyl)-4H-1,4-benzodiazepine-4-sulfonamide
• Synonyms: (3R)-7-Cyano-1,2,3,5-tetrahydro-N,N-dimethyl-3-(phenylmethyl)-4H-1,4-benzodiazepine-4-sulfonamide
• CAS NO: 195985-82-1
• Molecular Weight: 370.475
• Mol File: 195985-82-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3R)-7-Cyano-1,2,3,5-tetrahydro-N,N-dimethyl-3-(phenylmethyl)-4H-1,4-benzodiazepine-4-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-7-Cyano-1,2,3,5-tetrahydro-N,N-dimethyl-3-(phenylmethyl)-4H-1,4-benzodiazepine-4-sulfonamide(195985-82-1)
• EPA Substance Registry System: (3R)-7-Cyano-1,2,3,5-tetrahydro-N,N-dimethyl-3-(phenylmethyl)-4H-1,4-benzodiazepine-4-sulfonamide(195985-82-1)

Safety Data

• Hazardous Substances Data: 195985-82-1(Hazardous Substances Data)

Upstream product

• 13360-57-1 dimethylamino sulfonyl chloride 
• 195984-90-8 (R)-2,3,4,5-tetrahydro-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile 
• 195984-32-8 (R)-7-bromo-2,3,4,5-tetrahydro-3-(phenylmethyl)-1H-1,4-benzodiazepine-2,5-dione 
• 195984-33-9 (R)-7-bromo-2,3,4,5-tetrahydro-3-(phenylmethyl)-1H-1,4-benzodiazepine 

Relevant articles and documents

Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase

Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of the formulas their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs and solvates thereof.

Discovery of (R)-7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4- (2-thienysulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity

Continuing structure-activity studies were performed on the 2,3,4,5-tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepine farnesyltransferase (FT) inhibitors. These studies demonstrated that a 3(R)-phenylmethyl group, a hydrophilic 7-cyano group, and a 4-s