195987-08-7

Basic information

• Product Name: (R)-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine-7-carbonitrile
• Synonyms: (R)-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine-7-carbonitrile
• CAS NO: 195987-08-7
• Molecular Weight: 443.549
• Mol File: 195987-08-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine-7-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine-7-carbonitrile(195987-08-7)
• EPA Substance Registry System: (R)-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine-7-carbonitrile(195987-08-7)

Safety Data

• Hazardous Substances Data: 195987-08-7(Hazardous Substances Data)

Upstream product

• 3034-50-2 5-imidazolecarboxaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 195984-33-9 (R)-7-bromo-2,3,4,5-tetrahydro-3-(phenylmethyl)-1H-1,4-benzodiazepine 
• 195984-90-8 (R)-2,3,4,5-tetrahydro-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile 
• 195984-32-8 (R)-7-bromo-2,3,4,5-tetrahydro-3-(phenylmethyl)-1H-1,4-benzodiazepine-2,5-dione 

Downstream Products

• 1026414-72-1 (R)-7-cyano-4-[(2-chloroethyl)sulfonyl]-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4H-1,4-benzodiazepine 
• 195984-91-9 (R)-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile 

Relevant articles and documents

Discovery of (R)-7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4- (2-thienysulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity

Continuing structure-activity studies were performed on the 2,3,4,5-tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepine farnesyltransferase (FT) inhibitors. These studies demonstrated that a 3(R)-phenylmethyl group, a hydrophilic 7-cyano group, and a 4-s