196214-70-7

Basic information

• Product Name: N-phenethyl-L-Phe-OMe
• Synonyms: N-phenethyl-L-Phe-OMe
• CAS NO: 196214-70-7
• Molecular Weight: 283.37
• Mol File: 196214-70-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-phenethyl-L-Phe-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenethyl-L-Phe-OMe(196214-70-7)
• EPA Substance Registry System: N-phenethyl-L-Phe-OMe(196214-70-7)

Safety Data

• Hazardous Substances Data: 196214-70-7(Hazardous Substances Data)

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 203873-67-0 (S)-methyl 2-(2-nitrophenylsulfonamido)-3-phenylpropanoate 
• 1342305-88-7 N-(2-nitrophenyl)sulfonyl-N-phenethyl-L-Phe-OMe 

Downstream Products

• 1342305-92-3 (3S,4S)-4-benzyl-4-methoxycarbonyl-3-methyl-1-phenethyl-2-azetidinone 
• 1342305-86-5 (3S,4S)-4-benzyl-4-carboxy-3-methyl-1-phenethyl-2-azetidinone 
• 1342305-90-1 N-[(S)-2-chloropropionyl]-N-phenethyl-L-Phe-OMe 

Relevant articles and documents

Optically active 1,3,4,4-tetrasubstituted β-lactams: Synthesis and evaluation as tumor cell growth inhibitors

The in vitro cytotoxicity assays of several enantiopure (3S,4S)- and (3R,4R)-1,3,4,4-tetrasubstituted β-lactams derived from amino acids have shown that the (3S,4S)-4-benzyl-1-p-methoxybenzyl-3-methyl-4-methoxycarbonyl derivative 2a, obtained from Phe, displays significant activity, which is comparable to that of the anticancer drug Doxorubicin against HT29 cell lines. Modifications at positions 1 and 4 of the β-lactam ring led to identify the Tyr(2,6-ClBz) analogu 26d with similar activity data to those of 2a. The synthesis and SAR of all these tetrasubstituted β-lactams are reported here.