196596-88-0 Usage
General Description
2,5-ANHYDRO-3-DEOXY-3-(3,4-DIHYDRO-5-METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL)-L-MANNITOL, also known as lometrexol, is a chemical compound used as an antifolate agent in cancer treatment. It is a potent inhibitor of the enzyme dihydrofolate reductase, which plays a crucial role in DNA synthesis and cell proliferation. By blocking this enzyme, lometrexol disrupts the production of nucleotides necessary for DNA replication and cell division, ultimately leading to the inhibition of cancer cell growth. Lometrexol is being studied for its potential in the treatment of various types of cancer, including ovarian, lung, and breast cancer, and is often used in combination with other chemotherapy drugs. Its mechanism of action and potential for targeting cancer cells make it a promising candidate for further research and development in cancer therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 196596-88-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,6,5,9 and 6 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 196596-88:
(8*1)+(7*9)+(6*6)+(5*5)+(4*9)+(3*6)+(2*8)+(1*8)=210
210 % 10 = 0
So 196596-88-0 is a valid CAS Registry Number.
196596-88-0Relevant articles and documents
Synthesis of 3-deoxy-3-nucleobase-2,5-anhydro-D-mannitol: A novel class of hydroxymethyl-branched isonucleosides
Lei,Min,Zhang
, p. 2899 - 2906 (2007/10/03)
A concise synthesis of 3-deoxy-3-nucleobase-2,5-anhydro-D-mannitol 6(a- d) has been achieved, using the deamination of 2-amino-2-deoxy-D-glucose to construct in one step the sugar skeleton with the desired sense of chirality at each asymmetric center. The selective dibenzoylation of 2,5-anhydro-D- mannitol 9 was investigated, and the key epoxide intermediate 13 was obtained in good yield via an intramolecular Mitsunobu reaction. The process of opening of epoxide 13 by nucleobases appeared to be regioselective. (C) 2000 Elsevier Science Ltd.