19716-56-4Relevant articles and documents
Anionic Rearrangement of BF3-complexed N-Allyl and Aryl Tetrahydroisoquinolines.
Kessar, S. V.,Singh, Paramjit,Singh, Kamal Nain,Kaul, Vijay K.,Kumar, Gurdeep
, p. 8481 - 8484 (1995)
BF3-complexed N-Allyl and N-benzyl tetrahydroisoquinolines react, at -20 deg C to 0 deg C in THF, with sec-BuLi to give 1-substituted tetrahydroisoquinolines.
Photocatalytic deaminative benzylation and alkylation of tetrahydroisoquinolines with N-alkylpyrydinium salts
No?l, Timothy,Sambiagio, Carlo,Sch?nbauer, David,Schnürch, Michael
, p. 809 - 817 (2020/05/18)
A ruthenium-catalyzed photoredox coupling of substituted N-aryltetrahydroisoquinolines (THIQs) and different bench-stable pyridinium salts was successfully developed to give fast access to 1-benzyl-THIQs. Furthermore, secondary alkyl and allyl groups were also successfully introduced via the same method. Additionally, the typically applied N-phenyl group in the THIQ substrate could be replaced by the cleavable p-methoxyphenyl (PMP) group and successful N-deprotection was demonstrated.
4,5-Dihydrothiazoline - A new protecting and activating group for generation of α-aminocarbanions of secondary amines
Singh, Kamal Nain,Singh, Paramjit,Kaur, Amarjit
, p. 3339 - 3343 (2007/10/03)
4,5-Dihydrothiazoline has been successfully used as a protecting and activating group for synthesis of various 1-substituted 1,2,3,4- tetrahydroisoquinolines via a lithiation-electrophillic substitution reaction sequence. Copyright Taylor & Francis Group, LLC.