1978-86-5

Basic information

• Product Name: 1-(4-bromophenyl)-3-(2,4-difluorophenyl)thiourea
• Synonyms: 1-(4-bromophenyl)-3-(2,4-difluorophenyl)thiourea
• CAS NO: 1978-86-5
• Molecular Weight: 343.195
• Mol File: 1978-86-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-bromophenyl)-3-(2,4-difluorophenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromophenyl)-3-(2,4-difluorophenyl)thiourea(1978-86-5)
• EPA Substance Registry System: 1-(4-bromophenyl)-3-(2,4-difluorophenyl)thiourea(1978-86-5)

Safety Data

• Hazardous Substances Data: 1978-86-5(Hazardous Substances Data)

Upstream product

• 367-25-9 2,4-difluorophenylamine 
• 2493-02-9 4-bromophenyl isocyanate 
• 141106-52-7 2,4-difluorophenyl isothiocyanate 
• 106-40-1 4-bromo-aniline 

Relevant articles and documents

Synthesis, in vitro urease inhibitory activity, and molecular docking studies of thiourea and urea derivatives

The current study deals with the synthesis of urea and thiourea derivatives 1–37 which were characterized by various spectroscopic techniques including FAB-MS, 1H-, and 13C NMR. The synthetic compounds were subjected to urease inhibitory activity and compounds exhibited good to moderate urease inhibitory activity having IC50 values in range of 10.11–69.80 μM. Compound 1 (IC50 = 10.11 ± 0.11 μM) was found to be most active and even better as compared to the standard acetohydroxamic acid (IC50 = 27.0 ± 0.5 μM). A limited structure–activity relationship (SAR) was established and the compounds were also subjected to docking studies to confirm the binding interactions of ligands (compounds) with the active site of enzyme.