19815-97-5

Basic information

• Product Name: 2-BROMO-1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-1-ETHANONE
• Synonyms: 2-BROMO-1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-1-ETHANONE;5-(Bromoacetyl)-2,3-dihydro-1,4-benzodioxine;2-Bromo-1-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)ethanone;5-(Bromoacetyl)-1,4-benzodioxane, 2-Bromo-1-(2,3-dihydro-1,4-benzodioxin-5-yl)ethan-1-one
• CAS NO: 19815-97-5
• Molecular Formula: C10H9BrO3
• Molecular Weight: 257.08
• Mol File: 19815-97-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 71 °C
• Boiling Point: 348.076 °C at 760 mmHg
• Flash Point: 164.311 °C
• Appearance: /
• Density: 1.577 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-BROMO-1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-1-ETHANONE(19815-97-5)
• EPA Substance Registry System: 2-BROMO-1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-1-ETHANONE(19815-97-5)

Safety Data

• Hazard Codes: C
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 19815-97-5(Hazardous Substances Data)

Usage

General Description

2-BROMO-1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-1-ETHANONE is a chemical compound with the formula C10H9BrO3. It is a highly reactive and versatile compound that is commonly used in organic synthesis and medicinal chemistry. The presence of a bromine atom and a benzodioxin moiety in its structure makes it an important building block for various pharmaceutical and agrochemical products. It is also used as an intermediate in the synthesis of other organic compounds and is known for its potential biological activities, making it an important molecule in drug discovery and development. However, it is important to handle and use this chemical with caution due to its reactivity and potential health hazards.

InChI:InChI=1/C10H9BrO3/c11-6-8(12)7-2-1-3-9-10(7)14-5-4-13-9/h1-3H,4-6H2

Upstream product

• 4442-53-9 2,3-dihydro-1,4-benzodioxine-5-carboxylic acid 
• 915390-36-2 N-methoxy-N-methyl-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide 
• 29668-43-7 2,3-dihydro-benzo[1,4]dioxine-5-carbaldehyde 
• 19813-62-8 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-ethanone 

Relevant articles and documents

Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-β type 1 receptor inhibitors

Inhibition of transforming growth factor β (TGF-β) type 1 receptor (ALK5) provides a feasible approach for the treatment of fibrotic diseases and malignant tumors. In this study, we designed and synthesized a new series of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives, and evaluated biologically as TGF-β type 1 receptor inhibitors. The most potent compound 15r inhibited the ALK5 enzyme and NIH3T3 cell viability with IC50 values of 44 and 42.5 nM, respectively. Compound 15r also displayed better oral plasma exposure and excellent bioavailability than LY-3200882, and in vivo inhibited 65.7% of the tumor growth in a CT26 xenograft mouse model.