19837-75-3 Usage
General Description
4-AMINO-N-(4-ETHOXY-PHENYL)-BENZENESULFONAMIDE, also known as ethoxzolamide, is a sulfonamide derivative and a carbonic anhydrase inhibitor. It is used as a diuretic and as an antiglaucoma agent to reduce intraocular pressure. The compound works by inhibiting the action of carbonic anhydrase, an enzyme that is involved in the production of aqueous humor in the eye. By reducing the formation of this fluid, ethoxzolamide can help to lower intraocular pressure, which is important in the treatment of conditions such as glaucoma. Additionally, it has also shown potential in the treatment of epilepsy, as it can inhibit certain enzymes that are involved in seizure activity. Overall, 4-AMINO-N-(4-ETHOXY-PHENYL)-BENZENESULFONAMIDE has a range of therapeutic uses due to its inhibitory effects on various enzyme systems in the body.
Check Digit Verification of cas no
The CAS Registry Mumber 19837-75-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,8,3 and 7 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 19837-75:
(7*1)+(6*9)+(5*8)+(4*3)+(3*7)+(2*7)+(1*5)=153
153 % 10 = 3
So 19837-75-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H16N2O3S/c1-2-19-13-7-5-12(6-8-13)16-20(17,18)14-9-3-11(15)4-10-14/h3-10,16H,2,15H2,1H3
19837-75-3Relevant articles and documents
Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: Synthesis, structure-activity relationship analysis, and biological activity
Yu, Shenghui,Zhang, Linna,Yan, Shifeng,Wang, Peng,Sanchez, Tino,Christ, Frauke,Debyser, Zeger,Neamati, Nouri,Zhao, Guisen
, p. 628 - 640 (2012/10/29)
Four series of forty-five nitrogen-containing polyhydroxylated aromatics based on caffeic acid phenethyl ester were designed and synthesized as HIV-1 integrase (IN) inhibitors. Most of these compounds inhibited IN catalytic activities in low micromolar range. Among these new analogues, compounds 9e and 9f were the most potent IN inhibitors with IC50 value of 0.7 μM against strand transfer reaction. Their key structure-activity relationships were also discussed.
