19914-20-6 Usage
Description
Enniatin B1 is a cyclohexadepsipeptide ionophore, one of the four major analogues of the enniatin complex, produced by several Fusarium species. It is known for its antibiotic properties and its ability to form pores in cellular membranes for selective ion transport. Enniatin B1 has gained attention for its effects on acyl-CoA cholesterol transferase, transporters, and the selectivity of its antitumor action.
Uses
Used in Pharmaceutical Industry:
Enniatin B1 is used as an antitumor agent for its ability to induce apoptosis in several cancer lines (EC50s ≤ 10 μM) and decrease the activation of the cell proliferation kinase, ERK (p44/p42). It has shown potential in the development of novel drug delivery systems to enhance its applications and efficacy against cancer cells.
Used in Research and Development:
Enniatin B1 is used as a research tool for examining drug resistance mechanisms, particularly in its ability to inhibit the multi-drug resistance transporter Pdr5p from S. cerevisiae. This application aids in understanding and overcoming challenges related to drug resistance in cancer treatment.
Biochem/physiol Actions
Enniatins are a group of cyclohexadepsipeptide mycotoxins produced by Gnomonia errabuda and several Fusaria species, with phytotoxic, antibiotic, and insecticidal activities. Enniatins function as ionophors by their incorporation into the cellular membrane to form dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. It has been demonstrated that enniatins have a cytotoxic effect on human cancer cells. Furthermore, incubation of H4IIE hepatoma cells with enniatins strongly diminished phosphorylation of the ERK (p44/p42). Enniatins B and B1 inhibit the multi-drug resistance transporter Pdr5p from Saccharomyces cerevisiae, indicating their beneficial potential in cases of drug resistant patients.
Check Digit Verification of cas no
The CAS Registry Mumber 19914-20-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,9,1 and 4 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 19914-20:
(7*1)+(6*9)+(5*9)+(4*1)+(3*4)+(2*2)+(1*0)=126
126 % 10 = 6
So 19914-20-6 is a valid CAS Registry Number.
InChI:InChI=1/C34H59N3O9/c1-16-22(12)25-34(43)46-27(20(8)9)30(39)36(14)23(17(2)3)32(41)44-26(19(6)7)29(38)35(13)24(18(4)5)33(42)45-28(21(10)11)31(40)37(25)15/h17-28H,16H2,1-15H3