19924-43-7Relevant articles and documents
Preparation method of m-methoxyphenethylamine
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Paragraph 0017; 0049-0052; 0055-0058; 0061-0064, (2021/11/14)
The invention discloses a preparation method of m-methoxyethylamine, and relates to the field of organic synthesis preparation chemistry. The preparation method comprises the following steps: adding M-methoxybenzyl chloride to an aqueous solution of cyanide, carrying out cyanation reaction at 60 - 95 °C DEG C, generating M-methoxycyanide, and then cooling and crystallizing in acetone to obtain m-methoxycyanide crystals. A proper amount of ammonia gas is introduced into the solvent, then a proper amount of ammonia gas is introduced, and then hydrogen is introduced to carry out catalytic hydrogenation reaction at a temperature 110 - 160 °C, and the hydrogenated product is distilled under reduced pressure to obtain m-methoxyethylamine. The preparation method of the meta-methoxyethylamine is simple, the raw materials are easily available, the process is easy to control, the cost is low, and the method has the characteristics of high yield, high purity, environmental friendliness and the like, and is suitable for industrial production.
Crown ether functionalized magnetic hydroxyapatite as eco-friendly microvessel inorganic-organic hybrid nanocatalyst in nucleophilic substitution reactions: an approach to benzyl thiocyanate, cyanide, azide and acetate derivatives
Azaroon, Maedeh,Kiasat, Ali Reza
, (2017/10/09)
In this paper, high catalytic activity of 4′,4″-diformyl dibenzo-18-crown-6 anchored onto the functionalized magnetite hydroxyapatite (γ-Fe2O3@HAp–Crown) as a new, versatile and magnetically recoverable catalyst, was prepared. It evaluated as phase-transfer catalyst and molecular host system for nucleophilic substitution reactions of benzyl halides with thiocyanate, cyanide, azide and acetate anions in water. No evidence for the formation of by-products was observed and the products obtained in pure form without further purification. The nanocomposite was easily removed from solution via application of a magnetic field, allowing straightforward recovery and reuse. The synthesized nanocomposite was characterized by several techniques such as FT-IR, TGA-DTG, EDX, XRD, BET, FE-SEM, TEM and VSM.
Synthesis of α-aryl esters and nitriles: Deaminative coupling of α-aminoesters and α-aminoacetonitriles with arylboronic acids
Wu, Guojiao,Deng, Yifan,Wu, Chaoqiang,Zhang, Yan,Wang, Jianbo
supporting information, p. 10510 - 10514 (2016/02/18)
Transition-metal-free synthesis of α-aryl esters and nitriles using arylboronic acids with α-aminoesters and α-aminoacetonitriles, respectively, as the starting materials has been developed. The reaction represents a rare case of converting C(sp3)-N bonds into C(sp3)-C(sp2) bonds. The reaction conditions are mild, demonstrate good functional-group tolerance, and can be scaled up. Touch base: A transition-metal-free protocol for the synthesis of α-aryl esters and nitriles by deaminative coupling is presented. Strong bases and transition-metal catalysts are not needed. The new synthetic method uses readily available starting materials and demonstrates wide substrate scope.
