199285-47-7

Basic information

• Product Name: 4-Piperidinone, 2,6-bis(4-methoxyphenyl)-
• CAS NO: 199285-47-7
• Molecular Formula: C19H21NO3
• Molecular Weight: 311.381
• Mol File: 199285-47-7.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 4-Piperidinone, 2,6-bis(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinone, 2,6-bis(4-methoxyphenyl)-(199285-47-7)
• EPA Substance Registry System: 4-Piperidinone, 2,6-bis(4-methoxyphenyl)-(199285-47-7)

Safety Data

• Hazardous Substances Data: 199285-47-7(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 67-64-1 acetone 

Downstream Products

• 597577-95-2 C₂₀H₂₄N₄O₂S 
• 677007-21-5 1-hydroxy-2,6-bis-(4-methoxy-phenyl)-piperidin-4-one 
• 914295-45-7 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one 
• 677007-30-6 3-[2,6-bis-(4-methoxy-phenyl)-4-oxo-piperidin-1-yloxy]-propionitrile 
• 724701-59-1 1-[2-(benzoxazol-2-yl)ethoxy]-2,6-bis(p-methoxyphenyl)piperidin-4-one 
• 677007-39-5 1-[2-(benzimidazol-2-yl)ethoxy]-2,6-bis(p-methoxyphenyl)piperidin-4-one 
• 861882-18-0 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one thiosemicarbazone 
• 1170321-55-7 r-2,c-6-bis(p-methoxyphenyl)piperidin-4-one O-benzyloxime 
• 1276544-32-1 3-(2,6-bis(4-methoxyphenyl)piperidin-4-ylideneamino)-2-thioxoimidazolidin-4-one 
• 1370225-36-7 N-[2,6-bis-(4-methoxyphenyl)-piperidin-4-ylidene]-N'-(7-chloro-quinolin-4-yl)-hydrazine 
• 1461755-57-6 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-4-nitrobenzoyloxime 
• 1461755-60-1 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-2-hydroxybenzoyloxime 
• 1461755-61-2 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3-hydroxybenzoyloxime 
• 1461755-62-3 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-4-hydroxybenzoyloxime 

Relevant articles and documents

Synthesis of thiazole-based substituted piperidinone oximes: Profiling of antioxidant and antimicrobial activity

The synthesis of novel thiazole-based piperidinone oximes and screening of their antioxidant and antimicrobial activity are described. The obtained results revealed that the electronic effects of active substituents at C-4 terminals of phenyl rings on either side of piperidinone skeleton, as well as at 2-hydrazinyl thiazole, played a major role in development of antioxidant and antimicrobial activity. Antioxidant activity seems to be based also on radical dissipating ability of the thiazole ring. The nucleophilic character of sulfur in thiazole and lipophilic nature of piperidinone skeleton substantially influenced the observed antimicrobial activity of thiazole-based piperidinone oximes. Among the synthesized compounds, 2,6-bis(4-hydroxy-3-methoxyphenyl)-1-methylpiperidin-4-one O-(2-(2-(4-hydroxy-3-methoxybenzylidene)hydrazinyl)thiazol-4-yl) oxime exhibited excellent antioxidant activity whereas compound 2,6-bis(4-chloro phenyl)-1-methylpiperidin-4-one O-(2-(2-(4-nitrobenzylidene)hydrazinyl)thiazol-4-yl)oxime emerged as an outstanding antimicrobial agent.

Design, synthesis and in vitro antimalarial evaluation of new quinolinylhydrazone derivatives

A series of novel quinolinylhydrazones (5a-f) was synthesized by the condensation reaction of 2,6-diaryl-substituted piperidin-4-ones (4a-f) with 7-chloro-4-hydrazinoquinoline (2). Novel quinolinylhydrazones containing Shiff bases 8a-f and 11a-f were obta

Synthesis, spectral analysis and in vitro microbiological evaluation of 3-(3-alkyl-2,6-diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones as a new class of antibacterial and antifungal agents

In the present work, a new series of bis hybrid heterocycle comprising both piperidine and thiohydantoin nuclei together namely 3-(3-alkyl-2,6-diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones 46-60 was synthesized by the treatment of the respective thiosemicarbazones 31-45 with chloroethyl acetate and anhydrous sodium acetate in refluxing ethanol for 4 h and were characterized by melting point, elemental analysis, MS, FT-IR, one-dimensional NMR (1H, D2O exchanged 1H and 13C), two dimensional HOMOCOSY and NOESY spectroscopic data. In addition, the title compounds were screened for their antimicrobial activities against a spectrum of clinically isolated microbial organisms. Compounds 47-50, 52-55 and 57-60 with fluoro, chloro, methoxy or methyl functions at the para position of phenyl rings attached to C-2 and C-6 carbons of piperidine moiety along with and without methyl substituent at position C-3 of the piperidine ring exerted potent biological activities against Staphylococcus aureus, β-Hemolytic streptococcus, Vibrio cholerae, Escherichia coli, Pseudomonas aeruginosa, Aspergillus flavus, Candida albicans, Candida 6 and Candida 51 at a minimum inhibitory concentration.