19945-21-2

Basic information

• Product Name: O,O'-Trimethylen-bis-(phosphorsaeuredibenzylester)
• Synonyms: O,O'-Trimethylen-bis-(phosphorsaeuredibenzylester)
• CAS NO: 19945-21-2
• Molecular Weight: 596.554
• Mol File: 19945-21-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: O,O'-Trimethylen-bis-(phosphorsaeuredibenzylester)(CAS DataBase Reference)
• NIST Chemistry Reference: O,O'-Trimethylen-bis-(phosphorsaeuredibenzylester)(19945-21-2)
• EPA Substance Registry System: O,O'-Trimethylen-bis-(phosphorsaeuredibenzylester)(19945-21-2)

Safety Data

• Hazardous Substances Data: 19945-21-2(Hazardous Substances Data)

Upstream product

• 50651-75-7 silver dibenzylphosphate 
• 627-31-6 1,3-Diiodopropane 
• 990-91-0 dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate 
• 504-63-2 trimethyleneglycol 

Downstream Products

• 17662-32-7 O,O'-Trimethylen-bis-(phosphorsaeure-monobenzylester)-dinatriumsalz 

Relevant articles and documents

Selective phosphorylation of diols with a Lewis acid catalyst

We report a method for the Lewis acid catalyzed phosphorylation of diols with pyrophosphates. Titanium alkoxides were found to be effective catalysts in the selective mono-phosphorylation for a range of diols. Diols of varying chain lengths and substituents were screened, to study the factors that influence mono- versus di-phosphorylation. It was discovered that 2-alkyl-2-amino-1,3- propanediols can be selectively mono-phosphorylated in up to 97% isolated yield. This structural core is mono-phosphorylated in numerous immunomodulating compounds including the FDA-approved drug, FTY720.