199454-06-3Relevant articles and documents
Alkynyl β-sheet peptidomimetics retain their anti-parallel sheet conformation when coordinated to tungsten
Curran, Timothy P.,Boynton, Adam N.,Berk, Shawna M.,Pedro, Elena-Marie C.
, p. 31 - 36 (2015)
Abstract Peptide derivatives (8 and 9) of 2-amino-2′-carboxydiphenylacetylene (1) were prepared using the Sonogashira reaction and standard peptide chemistry. As reported earlier by Kemp and Li (Ref. [1]), 8 and 9 adopt anti-parallel β-sheet conformations
Pyrimidine or pyridine pyridine ketone compound and its preparation method and application (by machine translation)
-
, (2016/10/09)
The invention discloses a kind of type I of the pyrimidine or pyridine pyridine ketone compound and its preparation and application, which belongs to the technical field of pharmaceutical preparation. The compounds have high-efficient and selectively inhibit the cell cycle dependent kinases (Cdks) CDK4 and CDK6 active, and then by inhibiting CDK4/CDK6 prevent tumor cell division. Therefore, the compounds of this invention can be used for CDK4 and CDK6 the involved in cell cycle control disorders result in various diseases, especially suitable for the treatment of malignant tumors. (by machine translation)
Diversely Substituted Quinolines via Rhodium-Catalyzed Alkyne Hydroacylation
Neuhaus, James D.,Morrow, Sarah M.,Brunavs, Michael,Willis, Michael C.
supporting information, p. 1562 - 1565 (2016/05/02)
The Rh-catalyzed hydroacylative union of aldehydes and o-alkynyl anilines leads to 2-aminophenyl enones, and onward to substituted quinolines. The mild reaction conditions employed in this chemistry result in a process that displays broad functional group
