199864-86-3

Basic information

• Product Name: 2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride
• Synonyms: 2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride;2-AMino-4-(4-fluoronaphth-1-yl)-6-isopropylpyriMidine Monohydrochloride;MT 500 Hydrochloride;4-(4-Fluoro-1-naphthyl)-6-isopropylpyriMidin-2-aMine;4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine monohydrochloride;2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride
• CAS NO: 199864-86-3
• Molecular Formula: C17H17ClFN3
• Molecular Weight: 317.7883832
• Mol File: 199864-86-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 158 °C
• Appearance: white to tan/
• Storage Temp.: 2-8°C
• Solubility: DMSO: ≥20mg/mL
• CAS DataBase Reference: 2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride(199864-86-3)
• EPA Substance Registry System: 2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride(199864-86-3)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 199864-86-3(Hazardous Substances Data)

Usage

Description

2-Pyrimidinamine, 4-(4-fluoro-1-naphthalenyl)-6-(1-methylethyl)-, monohydrochloride is a chemical compound with a complex structure, characterized by its high affinity and selectivity for the serotonin 5-HT2B receptor. It is an orally bioavailable antagonist, which makes it a promising candidate for various pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
2-Pyrimidinamine, 4-(4-fluoro-1-naphthalenyl)-6-(1-methylethyl)-, monohydrochloride is used as a selective serotonin 5-HT2B receptor antagonist for the treatment of various conditions related to the serotonin system. Its high affinity (pKi=9.5) and 1,000-fold selectivity for the 5-HT2B receptor compared to other receptor and ion channel binding sites make it a valuable compound for targeted therapeutic interventions.
Used in Research and Development:
In the field of research and development, 2-Pyrimidinamine, 4-(4-fluoro-1-naphthalenyl)-6-(1-methylethyl)-, monohydrochloride serves as a valuable tool for studying the role of the serotonin 5-HT2B receptor in various physiological and pathological processes. Its high selectivity allows researchers to investigate the receptor's function without significant interference from other receptors or ion channels.