200435-16-1

Basic information

• Product Name: Phenylalanine, N-(phenylmethyl)-, methyl ester
• CAS NO: 200435-16-1
• Molecular Formula: C17H19NO2
• Molecular Weight: 269.343
• Mol File: 200435-16-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Phenylalanine, N-(phenylmethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phenylalanine, N-(phenylmethyl)-, methyl ester(200435-16-1)
• EPA Substance Registry System: Phenylalanine, N-(phenylmethyl)-, methyl ester(200435-16-1)

Safety Data

• Hazardous Substances Data: 200435-16-1(Hazardous Substances Data)

Upstream product

• 65027-12-5 2-(benzylamino)-3-phenylpropanoic acid 
• 15028-44-1 DL-phenylalanine methyl ester 
• 100-52-7 benzaldehyde 
• 5619-07-8 methyl 2-amino-3-phenylpropanoate hydrochloride 
• 100-39-0 benzyl bromide 
• 100-46-9 benzylamine 
• 68870-85-9 methyl 2-(benzylideneamino)-3-phenylpropionate 
• 842-74-0 4-benzylidene-2-phenyloxazole-5(4H)-one 

Downstream Products

• 857754-17-7 N-benzyl-N-(2,3-bis-methoxycarbonyl-propenyl)-phenylalanine methyl ester 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 21685-51-8 D-phenylalanine methyl ester 
• 1154737-86-6 (E)-N-benzyl-N-(3-phenyl-2-propenyl)phenylalanine methyl ester 
• 15028-44-1 DL-phenylalanine methyl ester 
• 53381-08-1 6-benzyl-5-hydroxy-pyridine-3,4-dicarboxylic acid dimethyl ester; hydrochloride 
• 855759-01-2 6-benzyl-5-benzyloxy-pyridine-3,4-dicarboxylic acid dimethyl ester 
• 58581-50-3 2-(Benzylidenamino)-3-phenylpropansaeure-methylester-N-oxid 

Relevant articles and documents

BF3·Et2O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant

A versatile metal- and base-free direct reductive amination of aldehydes with amines using formic acid as a reductant under the catalysis of inexpensive BF3·Et2O has been developed. A wide range of primary and secondary amines and diversely substituted aldehydes are compatible with this transformation, allowing facile access to various secondary and tertiary amines in high yields with wide functional group tolerance. Moreover, the method is convenient for the late-stage functionalization of bioactive compounds and preparation of commercialized drug molecules and biologically relevant N-heterocycles. The procedure has the advantages of simple operation and workup and easy scale-up, and does not require dry conditions, an inert atmosphere or a water scavenger. Mechanistic studies reveal the involvement of imine activation by BF3and hydride transfer from formic acid.

CATALYST COMPOUNDS

The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formulas: where ring B is either itself polycyclic, or ring B together with R is polycyclic. The catalysts of the invention are particularly effective in reductive amination procedures 10 which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.

2,4-Dinitrobenzenesulfonamides: A simple and practical method for the preparation of a variety of secondary amines and diamines

2,4-Dinitrobenzenesulfonamides, readily prepared from primary amines and 2,4-dinitrobenzenesulfonyl chloride, can be alkylated by the Mitsunobu reaction or by the conventional methods to give N,N-disubstituted sulfonamides in excellent yields. Since 2,4-dinitrobenzenesulfonamides can be removed without deprotecting 2-nitrobenzenesulfonamides, a wide variety of diamines could be prepared by the combined use of these protecting/activating groups.