20059-73-8

Basic information

• Product Name: 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE
• Synonyms: 2-(4-(AMINOMETHYL)PHENOXY)-N,N-DIMETHYLETHANAMINE;4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE;p-[2-(dimethylamino)ethoxy]benzylamine;P-[2-(Dimthylamino)ethoxy]benzylamine;4-[2-(Dimethylamino)Ethoxy]Ben;4-[2-(DIMETHYLAMINA) ETHOXY] BENZYLAMINE;4-(N,N-Dimethylaminoethoxy)benzylamine;4-[2-(DIMETHYLAMINA) 98+%
• CAS NO: 20059-73-8
• Molecular Formula: C₁₁H₁₈N₂O
• Molecular Weight: 194.27
• EINECS: 243-491-9
• Product Categories: PHARMACEUTICAL INTERMEDIATES;Aromatics;API intermediates
• Mol File: 20059-73-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 304.967 °C at 760 mmHg
• Flash Point: 138.245 °C
• Appearance: /
• Density: 1.021 g/cm³
• Vapor Pressure: 0.000845mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.29±0.10(Predicted)
• CAS DataBase Reference: 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE(20059-73-8)
• EPA Substance Registry System: 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE(20059-73-8)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 20059-73-8(Hazardous Substances Data)

Usage

General Description

4-[2-(Dimethylamino)ethoxy]benzylamine is a chemical compound with the molecular formula C12H19NO. It is a derivative of benzylamine with an ethoxy group and a dimethylamino group attached to the benzene ring. 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE is commonly used in pharmaceutical research and as a building block for the synthesis of various organic compounds. It is also used as a reagent for the preparation of novel drugs and as an intermediate in the production of other chemicals. 4-[2-(Dimethylamino)ethoxy]benzylamine has potential applications in the development of new drugs and as a key component in the creation of diverse chemical products.

InChI:InChI=1/C11H18N2O/c1-13(2)7-8-14-11-5-3-10(9-12)4-6-11/h3-6H,7-9,12H2,1-2H3

Upstream product

• 15182-92-0 4-(2-dimethylaminoethoxy)benzaldehyde 
• 140-75-0 para-fluorobenzylamine 
• 106-44-5 p-cresol 
• 131028-55-2 [2-(4-Chloromethyl-phenoxy)-ethyl]-dimethyl-amine 
• 13468-02-5 dimethyl(2-phenoxyethyl)amine 
• 108-95-2 phenol 
• 696-60-6 4-aminomethylphenol 
• 149505-94-2 tert-butyl (4-hydroxybenzyl)carbamate 
• 24197-95-3 4-(2-(dimethylamino)ethoxy)-benzonitrile 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 138-56-7 Trimethobenzamide 
• 122892-84-6 4-Dimethylamino-N-[4-(2-dimethylamino-ethoxy)-benzyl]-benzamide 
• 122892-39-1 2-amino-N-<4-<2-(dimethylamiono)ethoxy>benzyl>benzamide 
• 140836-59-5 N-[4-(2-Dimethylamino-ethoxy)-benzyl]-2-ethoxy-benzamide 
• 122892-78-8 N-[4-(2-Dimethylamino-ethoxy)-benzyl]-4-ethyl-benzamide 
• 122892-55-1 N-[4-(2-Dimethylamino-ethoxy)-benzyl]-4-ethoxy-benzamide 
• 122892-42-6 N-[4-(2-Dimethylamino-ethoxy)-benzyl]-2,4-dimethoxy-benzamide 
• 122892-59-5 N-[4-(2-Dimethylamino-ethoxy)-benzyl]-3-ethoxy-benzamide 
• 122892-60-8 N-[4-(2-Dimethylamino-ethoxy)-benzyl]-4-propoxy-benzamide 
• 122892-62-0 N-[4-(2-Dimethylamino-ethoxy)-benzyl]-3,4-diethoxy-benzamide 
• 122892-34-6 4-amino-5-chloro-N-<4-<2-(dimethylamino)ethoxy>benzyl>-2-methoxybenzamide 
• 122892-97-1 N-<4-<2-(dimethylamiono)ethoxy>benzyl>-3-sulfamoylbenzamide 
• 122892-38-0 N-[4-(2-Dimethylamino-ethoxy)-benzyl]-4-fluoro-benzamide 
• 122892-37-9 N-[4-(2-Dimethylamino-ethoxy)-benzyl]-4-sulfamoyl-benzamide 

Relevant articles and documents

Overcoming inaccessibility of fluorinated imines-synthesis of functionalized amines from readily available fluoroacetamides

Although imines are convenient substrates for the synthesis of functionalized amines, they may be hard to obtain, as in the case of fluorinated imines. To aid in overcoming this issue, we propose a protocol of corresponding amine synthesis from simple fluoroacetic acid-derived amides using Schwartz's reagent.

Preparation method of 4-[2-(dimethylamino)ethoxy]benzylamine

The invention provides a preparation method of 4-[2-(dimethylamino)ethoxy]benzylamine, comprising: allowing 4-hydroxybenzeneacetamide to react with 2-dimethylaminoethylchloride to obtain 4-[2-(dimethylamino)ethoxy]phenylacetamide, allowing the 4-[2-(dimethylamino)ethoxy]phenylacetamide to further react with sodium hypochlorite for Hofmann rearrangement to obtain 4-[2-(dimethylamino)ethoxy]benzylamine. The preparation method of the invention has the advantages that the synthetic route is short, raw materials are easy to obtain and cheap, the reactions are mild and convenient to perform, reaction yield is high, the quality is stable, and facilitated industrial production of the product is achieved.

Preparation method of itopride hydrochloride

The invention relates to a preparation method of itopride hydrochloride. The preparation method includes: using 2-dimethylaminoethyl chloride hydrochloride and phenol as starting materials for reaction; subjecting the starting materials to etherification, chloromethylation, amino substitution, amidation and salifying to obtain itopride hydrochloride. Chloromethylation promoted by C/CHO is adopted, so that a step of imine reduction is omitted, solid residue generated by a reductant is eliminated, and reaction safety is improved; raw materials used in the method are low in price, sufficient in market supply and easy to purchase; reaction in each step is classic, and the preparation method is safe, easy to control and suitable for industrial production.