200616-40-6

Basic information

• Product Name: Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester
• Synonyms: Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester;N-(9-Fluorenylmethyloxycarbonyl)-N-methyl-L-glutamic acid 5-tert-butyl ester;(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-5-tert-butoxy-5-oxopentanoic acid;REF DUPL: Fmoc-N-Me-Glu(OtBu)-OH;N-FMoc-N-Methyl-L-glutaMic acid 5-tert-butyl ester, 98%;Fmoc-N-methyl-L-glutamic acid γ-tert-butyl ester;Fmoc-N-Me-Glu(OtBu)-OH 97%;Fmoc-N-Me-L-Glu(OtBu)-OH
• CAS NO: 200616-40-6
• Molecular Formula: C25H29NO6
• Molecular Weight: 439.5
• Product Categories: N-Methyl Amino Acids;Fmoc-Amino acid series;amino acids;PROTECTED AMINO ACID & PEPTIDES;Glutamic acid [Glu, E]
• Mol File: 200616-40-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 116-119°C
• Boiling Point: 612.3 °C at 760 mmHg
• Flash Point: 324.1 °C
• Appearance: /
• Density: 1.22 g/cm³
• Vapor Pressure: 7.58E-16mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: -15°C
• PKA: 3.72±0.10(Predicted)
• CAS DataBase Reference: Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester(200616-40-6)
• EPA Substance Registry System: Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester(200616-40-6)

Safety Data

• Hazard Codes: N
• Statements: 50/53
• Safety Statements: 60-61
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 200616-40-6(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Uses

Fmoc-protected N-methyl amino acid. N-methyl amino acids have shown enhanced biological stability in peptides compared to standard amino acids.

InChI:InChI=1/C25H29NO6/c1-25(2,3)32-22(27)14-13-21(23(28)29)26(4)24(30)31-15-20-18-11-7-5-9-16(18)17-10-6-8-12-19(17)20/h5-12,20-21H,13-15H2,1-4H3,(H,28,29)/t21-/m0/s1

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 140837-98-5 (R)-2-(((benzyloxy)carbonyl)(methyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid 
• 51644-83-8 N-(benzyloxy)carbonyl-D-glutamic acid 5-tert-butyl ester 
• 45125-00-6 (R)-2-amino-5-(tert-butoxy)-5-oxopentanoic acid 

Downstream Products

• 879551-17-4 2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-pentanedioic acid 

Relevant articles and documents

Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions

The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.