200730-99-0

Basic information

• Product Name: (S)-2-trifluoroacetylamino-4-oxo-4-phenyl-butanoic acid
• Synonyms: (S)-2-trifluoroacetylamino-4-oxo-4-phenyl-butanoic acid
• CAS NO: 200730-99-0
• Molecular Weight: 289.211
• Mol File: 200730-99-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-2-trifluoroacetylamino-4-oxo-4-phenyl-butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-trifluoroacetylamino-4-oxo-4-phenyl-butanoic acid(200730-99-0)
• EPA Substance Registry System: (S)-2-trifluoroacetylamino-4-oxo-4-phenyl-butanoic acid(200730-99-0)

Safety Data

• Hazardous Substances Data: 200730-99-0(Hazardous Substances Data)

Upstream product

• 777-33-3 N-trifluoroacetyl-L-aspartic acid anhydride 
• 71-43-2 benzene 

Downstream Products

• 119817-54-8 (S)-2-amino-4-oxo-4-phenyl-butanoic acid 
• 221122-72-1 (S)-2-benzyloxycarbonylamino-4-oxo-4-phenyl-butanoyl azepanine 
• 221122-71-0 (S)-2-benzyloxycarbonylamino-4-oxo-4-phenyl-butanoyl piperidine 
• 221122-70-9 (S)-2-benzyloxycarbonylamino-4-oxo-4-phenyl-butanoyl pyrrolidine 
• 221122-68-5 2-trifluoroacetylamino-4-oxo-4-phenyl-butanoyl azepanine 
• 221122-67-4 2-trifluoroacetylamino-4-oxo-4-phenyl-butanoyl piperidine 
• 221122-69-6 (S)-2-benzyloxycarbonylamino-4-oxo-4-phenyl-butanoyl azetidine 

Relevant articles and documents

A Simple Approach to β-Amino Acids by Acylation of Arenes with N-Acyl Aspartic Anhydrides

Friedel-Crafts acylation of arenes (benzene, toluene, o-xylene) with N-protected (Bz, Ac, Ac-Bn, Ts, Tfac, N,N-Pht) aspartic anhydrides (1a-1f) resulted in mixtures of α- and β-amino acids. The β/ α-selectivity could be optimized for alkylated arenes (toluene, xylene) and the N-Ac, N-Bn protected 1c.

Regio- and stereoselective 1,6-photocyclization of aspartic acid- derived chiral γ-ketoamides[1]

Chiral α-acylamino γ-ketoamides 2 were irradiated and regioisomeric 1,6-cyclization products 3 and 4 obtained in high yields. Symmetrically N,N- disubstituted substrates 2a,b reacted diastereoselectively to give the all- cis products 3a,b in high yields. High 1,3-asymmetric induction was also observed for the unsymmetrically N,N-disubstituted 2d and 2e. The stereoselectivity of these reactions is discussed in terms of SOC-controlled spin inversion geometries.