201609-38-3Relevant articles and documents
Propafenone analogue with additional H-bond acceptor group shows increased inhibitory activity on P-glycoprotein
Cseke, Anna,Decker, Simon,Ecker, Gerhard F.,Jain, Sankalp,Schwarz, Theresa,Urban, Ernst,Vogl, Kerstin
, (2020/01/21)
P-glycoprotein (P-gp) is an ATP-dependent efflux pump that has a marked impact on the absorption, distribution, and excretion of therapeutic drugs. As P-gp inhibition can result in drug–drug interactions and altered drug bioavailability, identifying molec
Cyclic hexapeptides having antibiotic activity
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, (2008/06/13)
This invention relates to new polypeptide compound represented by general formula (I), wherein R1, R2, R3, R4, R5 and R6 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.