20172-29-6

Basic information

• Product Name: N-(4-methylphenyl)butanamide
• Synonyms: butanamide, N-(4-methylphenyl)-
• CAS NO: 20172-29-6
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.2429
• Mol File: 20172-29-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 332.6°C at 760 mmHg
• Flash Point: 196.7°C
• Density: 1.031g/cm³
• Vapor Pressure: 0.000144mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: N-(4-methylphenyl)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methylphenyl)butanamide(20172-29-6)
• EPA Substance Registry System: N-(4-methylphenyl)butanamide(20172-29-6)

Safety Data

• Hazardous Substances Data: 20172-29-6(Hazardous Substances Data)

Upstream product

• 541-35-5 butanamide 
• 624-31-7 4-tolyl iodide 
• 14618-59-8 N-(tert-butoxycarbonyl)-4-methylaniline 
• 86065-10-3 O-allyl-N-(4-methylphenyl)carbamate 
• 622-58-2 p-Tolylisocyanate 
• 7625-64-1 p-tolyl-carbamic acid benzyl ester 
• 5856-82-6 butyryl bromide 
• 106-49-0 p-toluidine 
• 10387-24-3 N-butyl-4-methylaniline 
• 106-31-0 butanoic acid anhydride 
• 501-60-0 1,2-di(p-tolyl)diazene 
• 4641-49-0 Bis-(3-p-tolylcarbamoyl-propyl)-sulfoxid 
• 107-92-6 butyric acid 
• 621-01-2 N,N'-Bis(p-tolyl)thiourea 

Downstream Products

• 501-60-0 1,2-di(p-tolyl)diazene 
• 10387-24-3 N-butyl-4-methylaniline 

Relevant articles and documents

Practical one-pot amidation of N -Alloc-, N -Boc-, and N -Cbz protected amines under mild conditions

A facile one-pot synthesis of amides from N-Alloc-, N-Boc-, and N-Cbz-protected amines has been described. The reactions involve the use of isocyanate intermediates, which are generated in situ in the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, to react with Grignard reagents to produce the corresponding amides. Using this reaction protocol, a variety of N-Alloc-, N-Boc-, and N-Cbz-protected aliphatic amines and aryl amines were efficiently converted to amides with high yields. This method is highly effective for the synthesis of amides and offers a promising approach for facile amidation.

Organocatalytic and enantioselective [4+2] cyclization between hydroxymaleimides and: Ortho -hydroxyphenyl para -quinone methide-selective preparation of chiral hemiketals

A cinchona alkaloid squaramide promoted enantioselective [4+2] cyclization between hydroxymaleimides and ortho-hydroxyphenyl p-QMs has been disclosed, and a wide range of chiral hemiketals containing chromane and succinimide frameworks with two adjacent quaternary stereogenic centers have been prepared for the first time with excellent results (up to 99% yield, up to 99?:?1 dr, up to >99% ee) under mild conditions. This journal is

Palladium-Catalyzed α-Arylation of Carboxylic Acids and Secondary Amides via a Traceless Protecting Strategy

A novel traceless protecting strategy is presented for the long-standing challenge of conducting the palladium-catalyzed α-arylation of carboxylic aids and secondary amides with aryl halides. Both of the presented coupling processes occur with a variety of carboxylic acids and amides and with a variety of aryl bromides containing a broad range of functional groups, including base-sensitive functionality like acyl, alkoxycarbonyl, nitro, cyano, and even hydroxyl groups. Five commercial drugs were prepared through this method in one step in 81-96% yield. Gram-scale synthesis of medication Naproxen and Flurbiprofen with low palladium loading further highlights the practical value of this method.