201730-11-2 Usage
Uses
(S)-3,4-DCPG is a potent and selective mGluR-8a agonist.
Biological Activity
Potent, selective mGlu 8a agonist (EC 50 = 31 nM). Displays > 100-fold selectivity over mGlu 1-7 and displays little or no activity at NMDA and kainate receptors. Increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo . Also potent anticonvulsant in mice in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 201730-11-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,1,7,3 and 0 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 201730-11:
(8*2)+(7*0)+(6*1)+(5*7)+(4*3)+(3*0)+(2*1)+(1*1)=72
72 % 10 = 2
So 201730-11-2 is a valid CAS Registry Number.
201730-11-2Relevant articles and documents
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes
Sekiyama,Hayashi,Nakanishi,Jane,Tse,Birse,Watkins
, p. 1493 - 1503 (1996)
1. We investigated the agonist and antagonist activities of 22 new phenylglycine and phenylalanine derivatives for metabotropic glutamate receptors (mGluRs) by examining their effects on the signal transduction of mGluR1, mGluR2 and
