20178-22-7

Basic information

• Product Name: 1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-1-methyl-5-oxo-2-phenyl-, ethyl ester
• CAS NO: 20178-22-7
• Molecular Formula: C14H15NO4
• Molecular Weight: 261.277
• Mol File: 20178-22-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-1-methyl-5-oxo-2-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-1-methyl-5-oxo-2-phenyl-, ethyl ester(20178-22-7)
• EPA Substance Registry System: 1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-1-methyl-5-oxo-2-phenyl-, ethyl ester(20178-22-7)

Safety Data

• Hazardous Substances Data: 20178-22-7(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 74-89-5 methylamine 
• 40876-98-0 sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate 
• 88330-76-1 diethyl oxalacetate sodium salt 
• 55404-27-8 N-methyl-3-etoxycarbonyl-2-phenyl-Δ²-pyrroline-4,5-dione 
• 64-17-5 ethanol 

Downstream Products

• 55404-23-4 4-methoxy-1-methyl-5-oxo-2-phenyl-2,5-dihydro-pyrrole-3-carboxylic acid ethyl ester 
• 194029-67-9 1-methyl-5-oxo-2-phenyl-4,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis and bioactivity of some 2-oxo-5-aryl-3-hydrazone and 2-oxo-5-aryl-4-hydrazone pyrrolidine derivatives

2-Aryl-4,5-dioxopyrrolidine-3-carboxylate and 5-aryl-2,4-dioxopyrrolidine- 3-carboxylate derivatives were successfully synthesized via carbonyl-based multiple component reaction and Dieckmann cyclization, respectively. Successive functional group transformations which include decarboxylation and hydrazonation afforded 2-oxo-5-aryl-3-hydrazone and 2-oxo-5-aryl-4-hydrazone derivatives. Compound 3d exhibited activity against human histiocytic lymphoma (U937) and neuroblastoma (SH-SY5Y) cell lines while compound 6 showed neuroprotective ability from oxidative stress medium induced with H2O2.

Synthesis of 5-aryl-2-oxopyrrole derivatives as synthons for highly substituted pyrroles

A small library of 2-oxo-5-(hetero)arylpyrroles was prepared starting from 2,3-dioxo-5-(hetero)arylpyrrolidines. The large synthetic possibilities of these 2-oxopyrroles were investigated. The 2-oxopyrroles offer a large number of possible derivatizations