20198-18-9

Basic information

• Product Name: 4(3H)-Quinazolinone, 2-amino-7-chloro-
• Synonyms: 4(3H)-Quinazolinone, 2-amino-7-chloro-;2-AMINO-7-CHLORO-3,4-DIHYDROQUINAZOLIN-4-ONE
• CAS NO: 20198-18-9
• Molecular Formula: C8H6ClN3O
• Molecular Weight: 195.60574
• Mol File: 20198-18-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4(3H)-Quinazolinone, 2-amino-7-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 2-amino-7-chloro-(20198-18-9)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 2-amino-7-chloro-(20198-18-9)

Safety Data

• Hazardous Substances Data: 20198-18-9(Hazardous Substances Data)

Upstream product

• 4743-17-3 5-Chloroisatoic anhydride 
• 14527-26-5 2-methylisothiourea sulphate 
• 147895-43-0 S-methylisothiourea hemisulphate 
• 40928-13-0 4-chloroisatoic anhydride 
• 6828-35-9 5-chloro-2-iodoaniline 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 1184-90-3 aminoiminomethanesulfonic acid 

Relevant articles and documents

A new reaction of aminoiminomethanesulfonic acid with methyl anthranilates

A new double guanidinylation and cyclization reaction of aminoiminomethanesulfonic acid with methyl anthranilates to yield 5H- quinazolino[3,2-a]quinazoline-5,12 (6H)-diones is described.

Synthesis of 2-Aminoquinazolinones via Carbonylative Coupling of ortho-Iodoanilines and Cyanamide

Herein, we describe a convenient and efficient synthesis of 2-aminoquinazolin-4(3H)-ones and N1-substituted 2-aminoquinazolin-4(1H)-ones by a domino carbonylation/cyclization process. The reaction proceeds via carbonylative coupling of readily available ortho-iodoanilines with cyanamide followed by in situ ring closure of an N-cyanobenzamide intermediate. The products were easily isolated by precipitation in moderate to excellent yields for a wide range of substrates, making this a highly attractive method for the synthesis of 2-aminoquinazolinones.

HETEROCYCLIC SUBSTITUTED 2-AMINO-QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS

This invention relates to heterocyclic substituted 2-amino-quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES

This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll - like - receptors is involved.