201996-60-3 Usage
Description
5-METHYL-[1'-13C]URIDINE, also known as Labeled 5-Methyluridine, is a primary degradation product of tRNA. It is a urinary nucleoside that has been identified as a biological marker for patients with colorectal cancer. The presence of 5-METHYL-[1'-13C]URIDINE in urine can provide valuable information for the diagnosis and monitoring of colorectal cancer.
Uses
Used in Biomedical Research:
5-METHYL-[1'-13C]URIDINE is used as a research tool for studying the metabolism and degradation of tRNA in various biological processes. Its stable isotope labeling allows for the tracking of tRNA fragments and their role in cellular functions.
Used in Colorectal Cancer Diagnosis:
5-METHYL-[1'-13C]URIDINE is used as a biomarker for the detection and monitoring of colorectal cancer in patients. The presence of this urinary nucleoside can indicate the presence of the disease, aiding in early diagnosis and treatment planning.
Used in Clinical Trials and Drug Development:
5-METHYL-[1'-13C]URIDINE can be used as a biomarker in clinical trials to assess the efficacy of new drugs or treatments for colorectal cancer. By monitoring the levels of this nucleoside in patients, researchers can evaluate the effectiveness of the treatment and make necessary adjustments.
Used in Personalized Medicine:
5-METHYL-[1'-13C]URIDINE can be utilized in the field of personalized medicine to tailor treatment plans for individual patients based on their unique biomarker profiles. This can lead to more effective and targeted therapies for colorectal cancer patients.
Used in Epidemiological Studies:
5-METHYL-[1'-13C]URIDINE can be employed in epidemiological studies to investigate the prevalence and risk factors of colorectal cancer in different populations. This information can be used to develop targeted prevention and intervention strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 201996-60-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,1,9,9 and 6 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 201996-60:
(8*2)+(7*0)+(6*1)+(5*9)+(4*9)+(3*6)+(2*6)+(1*0)=133
133 % 10 = 3
So 201996-60-3 is a valid CAS Registry Number.
201996-60-3Relevant articles and documents
Phenylsulfenyl D-Ribofuranosides as Efficient Ribosyl Donors: Application to the Synthesis of -(Deoxy)Nucleosides
Chanteloup, Luc,Beau, Jean-Marie
, p. 5347 - 5350 (2007/10/02)
Readily available phenylsulfenyl 2,3,5-tri-O-benzoyl-β-D-ribofuranoside glycosylates silylated nucleobases in a fast, high-yielding and stereoselective reaction promoted by trimethylsilyl trifluoromethanesulfonate.The method has been applied to the synthesis of labelled nucleosides further transformed to building blocks ready for oligodeoxynucleotide construction. Key words: anomeric sulfoxides; silylated nucleobases; nucleosides; 2'-deoxynucleosides.
