202865-66-5

Basic information

• Product Name: 2-Bromo-5-fluorobenzyl alcohol
• Synonyms: RARECHEM AL BD 0749;2-BROMO-5-FLUOROBENZYL ALCOHOL;BUTTPARK 87\01-69;2-Ethoxy-4-fluorobromobenzene;(2-Bromo-5-fluorophenyl)methanol;2-Ethoxy-4-fluorobroMobenzene[2-broMo-5-fluorophenetole];Benzenemethanol,2-bromo-5-fluoro-
• CAS NO: 202865-66-5
• Molecular Formula: C₇H₆BrFO
• Molecular Weight: 205.02
• Product Categories: Alcohol;Miscellaneous;Alcohols;Bromine Compounds;Fluorine Compounds;C7 to C8;Oxygen Compounds;Fluorine series
• Mol File: 202865-66-5.mol
• Article Data: 30

Chemical Properties

• Melting Point: 91-94 °C
• Boiling Point: 252.5 °C at 760 mmHg
• Flash Point: 106.5 °C
• Appearance: Yellow/Solid
• Density: 1.658 g/cm³
• Vapor Pressure: 0.0502mmHg at 25°C
• Storage Temp.: Room temperature.
• PKA: 13.67±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-Bromo-5-fluorobenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-fluorobenzyl alcohol(202865-66-5)
• EPA Substance Registry System: 2-Bromo-5-fluorobenzyl alcohol(202865-66-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 202865-66-5(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

2-Bromo-5-fluorobenzyl alcohol is used as intermediates in pharmaceutical and organic synthesis.

InChI:InChI=1/C7H7BrFN.ClH/c8-7-2-1-6(9)3-5(7)4-10;/h1-3H,4,10H2;1H

Upstream product

• 94569-84-3 2-bromo-5-fluorobenzaldehyde 
• 6942-39-8 methyl 2-bromo-5-fluorobenzoate 
• 394-28-5 2-Bromo-5-fluorobenzoic acid 
• 452-63-1 2-Bromo-5-fluorotoluene 
• 112399-50-5 2-bromo-5-fluorobenzyl bromide 

Downstream Products

• 94569-84-3 2-bromo-5-fluorobenzaldehyde 
• 880104-86-9 4-methyl-benzenesulfinic acid 2-bromo-5-fluoro-benzyl ester 
• 842167-64-0 2-[(benzyloxy)methyl]-1-bromo-4-fluorobenzene 
• 700-85-6 5-fluoroisobenzofuran-1(3H)-one 
• 1004779-86-5 (5-bromo-2-fluoro-4-hydroxymethylphenyl)methanol 

Relevant articles and documents

Benzoxaborole-1-alcohol compound and preparation method and application thereof

The invention belongs to the field of bactericides, and particularly relates to a benzoxaborole-1-alcohol compound and a preparation method and application thereof. The benzoxaborole-1-alcohol compound has good bactericidal activity, can effectively control tomato early blight, wheat scab, rice sheath blight disease, strawberry gray mold, apple blotch, cucumber anthracnose and other crop diseases,can produce excellent antibacterial effects at low concentration, and shows good selectivity. The compound is used as a leucyl-tRNA synthetase inhibitor, the evolution difference of aminoacyl-tRNA synthetase of germs and eukaryotes is utilized, and the compound has very high safety to non-target organisms while killing the germs and can be used as a bactericide in agriculture.

Metal- and Hydride-Free Pentannulative Reductive Aldol Reaction

Traditionally, the reductive aldol reaction is a metal-catalyzed and hydride-promoted coupling between enones and aldehydes. We present a phosphine-mediated diastereoselective intramolecular reductive aldol reaction of α-substituted dienones and aldehydes, which is metal-free and hydride-free. The synthetic utility of the reductive aldol adducts is demonstrated by elaborating them in one step to indeno[1,2-b]furanones, indeno[1,2-b]pyrans, and dibenzo[a,h]azulen-8-ones.

Indolone derivative as well as preparation method and application thereof

The invention relates to a compound represented by formula (A) or a pharmaceutically acceptable salt, a stereoisomer, a tautomer, a polymorphic substance, a solvate, a metabolite or a prodrug thereof,and also relates to a pharmaceutical composition containing the compound. The compound can be used for treating cancer or immune system diseases.