20295-34-5 Usage
Description
Cyclopropanecarbothioamide is used for purification of thiazolo [5, 4-b] pyridine-and thiazolo [5, 4-c] pyridine derivatives from chloronitropyridines and thioamides, or thioureas during the simple-step reaction. It is also a useful chemical during the proteomics study. Recent study has also used it for synthesis of a novel heterocyclic compound, CE-125, which can improve working memory in the radial arm maze and modulate the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat.
Uses
Cyclopropanecarbothioamide is used for purification in single-step preparation of thiazolo [5, 4-b] pyridine-and thiazolo [5, 4-c] pyridine derivatives from chloronitropyridines and thioamides, or thioureas.
References
https://www.alfa.com/en/catalog/H32315/
Hussein, A. M., et al. "A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat." Behavioural Brain Research 332(2017):308-315.
Check Digit Verification of cas no
The CAS Registry Mumber 20295-34-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,2,9 and 5 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 20295-34:
(7*2)+(6*0)+(5*2)+(4*9)+(3*5)+(2*3)+(1*4)=85
85 % 10 = 5
So 20295-34-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H7NS/c5-4(6)3-1-2-3/h3H,1-2H2,(H2,5,6)
20295-34-5Relevant articles and documents
Preparation of primary thioamides from nitriles using sodium hydrogen sulfide and diethylamine hydrochloride
Boys, Mark L.,Downs, Victoria L.
, p. 295 - 298 (2006)
Primary thioamides are prepared in moderate to excellent yields by treating nitriles with sodium hydrogen sulfide and diethylamine hydrochloride in an appropriate solvent with mild heating. Copyright Taylor & Francis LLC.
Domino aryne precursor: Efficient construction of 2,4-disubstituted benzothiazoles
Shi, Jiarong,Qiu, Dachuan,Wang, Juan,Xu, Hai,Li, Yang
supporting information, p. 5670 - 5673 (2015/05/20)
An aryne precursor with a potential to perform domino aryne chemistry was proposed and synthesized. The reaction of this reagent with benzothioamide derivatives could afford 2,4-disubstituted benzothiazole with sequential incorporation of C-S, C-N, and C-C bonds on the consecutive three positions of the aryne precursor.
2-CYCLOPROPYL-THIAZOLE DERIVATIVES
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Page/Page column 12; 22, (2010/09/07)
The invention relates to selected 2-cyclopropyl-thiazole derivatives of the formula (I) wherein B, Y and R1 are as described in the description; to salts and especially pharmaceutically acceptable salts thereof, and to the use of such compounds use as med