20300-59-8Relevant articles and documents
Quantification of azide groups on a material surface and a biomolecule using a clickable and cleavable fluorescent compound
Sakai, Rika,Iguchi, Hiroki,Maruyama, Tatsuo
, p. 4621 - 4625 (2019)
Here, we propose a novel method for quantifying azide groups on a solid surface and a protein using a clickable and cleavable fluorescent compound. The clickable and cleavable fluorescent compound conjugates with the azide groups on the material surface a
ZrOCl2 · 8H2O: An efficient catalyst for rapid one-pot synthesis of 3-carboxycoumarins under ultrasound irradiation in water
Bardajee, Ghasem Rezanejade,Jafarpour, Farnaz,Afsari, Hamid Samareh
, p. 370 - 374 (2010)
In this report, a rapid, efficient and environmental friendly synthesis of 3-carboxycoumarins under ultrasound irradiation in water media is described. The Knoevenagel condensation of Meldrum's acid with substituted benzaldehydes in the presence of zirconium oxide chloride (ZrOCl2·8H2O) and ultrasonic irradiation in water gave the corresponding 3-carboxycoumarins in good to excellent yields.
A practical and environmentally friendly preparation of 3-carboxycoumarins
Deshmukh,Burud, Rahila,Baldino, Carmen,Chan, Philip C. M.,Liu, Jifeng
, p. 3299 - 3303 (2003)
The condensation of salicylaldehydes with Meldrum's acid in water at 75°C to produce 3-carboxycoumarin derivatives is described.
Solid phase synthesis of substituted coumarin-3-carboxylic acids via the Knoevenagel condensation
Watson, Brett T.,Christiansen, Gerda E.
, p. 6087 - 6090 (1998)
A solid phase synthesis of substituted coumarin-3-carboxylates using the Knoevenagel condensation reaction between ethyl malonate bound to the Wang resin and ortho-hydroxyarylaldehydes is described. The reaction has been shown to proceed cleanly to give the desired products.
A convenient synthesis of coumarin-3-carboxylic acids via Knoevenagel condensation of Meldrum's acid with ortho-hydroxyaryl aldehydes or ketones
Song, Aimin,Wang, Xiaobing,Lam, Kit S.
, p. 1755 - 1758 (2003)
Coumarin-3-carboxylic acids were obtained in high yields with excellent purity from ortho-hydroxybenzaldehydes and Meldrum's acid after a 2 h reflux in ethanol. The less reactive ketones were first reacted with alcoholic ammonia to form ketimines, which were then condensed with Meldrum's acid to generate 4-alkylcoumarin-3-carboxylic acids in moderate yields.
Method for synthesizing coumarin-3-carboxylic acid compounds by one-pot two-step method
-
Paragraph 0053; 0056; 0058; 0073; 0079; 0084-0090, (2021/06/12)
The invention relates to a method for synthesizing coumarin-3-carboxylic acid compounds by a one-pot two-step method. The structural formula of the coumarin-3-carboxylic acid compounds is shown in the description, wherein R1 is H , Cl , Br, NO2 , CH3 and HO . According to the synthesis process of the coumarin-3-carboxylic acid compounds, malonic acid, acetone and substituted salicylaldehyde serve as raw materials, iodine serves as a catalyst, acetic anhydride serves as a solvent, a series of coumarin-3-carboxylic acid compounds are synthesized through a one-pot cascade reaction, and the efficiency and the yield are greatly improved compared with a fractional step method.
3 - Coumarin formic acid compound and application thereof as antibacterial agent for preparing plant pathogenic bacteria
-
Paragraph 0039; 0044-0045; 0050-0051, (2021/03/24)
The invention relates to a compound with simple structure for inhibiting growth activity of phytopathogens, specifically relates to a 3-coumarin formic acid compound and application of the 3-coumarin formic acid compound as an antibacterial agent for preparing the phytopathogens, and discloses application of the 3-coumarin formic acid compound as the antibacterial agent for preparing the phytopathogens. The two 3-coumarin formic acid compounds has the following characteristics of molecular structure: the formulas are as shown in the specification, wherein R is hydrogen, methyl, methoxyl, hydroxyl, halogen and nitryl. The in vitro inhibitory activity of twenty-eight synthetic target compounds on four common plant pathogenic fungi such as apple decay pathogenic bacteria, apple ring spot pathogenic bacteria, maize curvularia pathogenic bacteria and potato dry rot pathogenic bacteria is measured by adopting a hypha linear growth rate method, so that the condition that all compounds have different inhibiting effects on supplied experimental bacteria is found.