20324-32-7

Basic information

• Product Name: 1-(2-methoxy-1-methylethoxy)propan-2-ol
• Synonyms: 1-(2-methoxy-1-methylethoxy)propan-2-ol;2-Propanol, 1-(2-methoxy-1-methylethoxy)-;1-(2-METHOXY)PROPANOL-2;2-PROPANOL,1-(2-METHOXY-1-MET;diisopropylene glycol monomethyl ether;(2-Hydroxypropyl)(1-methyl-3-oxabutane-1-yl) ether;1,4-Dimethyl-3,6-dioxaheptane-1-ol;5-Methyl-4,7-dioxaoctane-2-ol
• CAS NO: 20324-32-7
• Molecular Formula: C₇H₁₆O₃
• Molecular Weight: 148.20014
• EINECS: 243-733-3
• Mol File: 20324-32-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 203.3°Cat760mmHg
• Flash Point: 76.7°C
• Appearance: /
• Density: 0.955g/cm³
• PKA: 14.41±0.20(Predicted)
• CAS DataBase Reference: 1-(2-methoxy-1-methylethoxy)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methoxy-1-methylethoxy)propan-2-ol(20324-32-7)
• EPA Substance Registry System: 1-(2-methoxy-1-methylethoxy)propan-2-ol(20324-32-7)

Safety Data

• Hazardous Substances Data: 20324-32-7(Hazardous Substances Data)

Usage

General Description

1-(2-methoxy-1-methylethoxy)propan-2-ol is a chemical compound that is also known as dipropylene glycol methyl ether. It is a colorless liquid that is commonly used as a solvent in various industrial and household products. It has a high boiling point and low volatility, making it suitable for use in applications where controlled evaporation is desired. It is also used as a solvent in paints, coatings, and inks, as well as in cleaning products and as a coupling agent in chemical reactions. Additionally, it is known for its low toxicity and ability to dissolve a wide range of substances, making it a versatile and useful chemical in various industries.

InChI:InChI=1/C3H8O2.2C3H6/c1-5-3-2-4;2*1-3-2/h4H,2-3H2,1H3;2*3H,1H2,2H3

Synthetic route

sodium methylate (124-41-4) + methyloxirane (75-56-9, 16033-71-9) → propylene glycol monomethyl ether dimer (20324-32-7)

Conditions	Yield
In methanol

methanol (67-56-1) + methyloxirane (75-56-9, 16033-71-9) → 1-methoxy-2-propanol (107-98-2) + propylene glycol monomethyl ether dimer (20324-32-7)

Conditions	Yield
With sodium hydroxide at 85℃; Heating; Yield given. Yields of byproduct given;
With sodium hydroxide at 85℃; Heating; Yield given. Yields of byproduct given;

1-methoxy-2-propanol (107-98-2) + methyloxirane (75-56-9, 16033-71-9) + sodium-<β-methoxy isopropylate > → propylene glycol monomethyl ether dimer (20324-32-7)

propylene glycol monomethyl ether dimer (20324-32-7) → Dipropylene glycol (106-62-7)

Conditions	Yield
With hydrogen bromide

propylene glycol monomethyl ether dimer (20324-32-7) + 2,2'-bipyridyl-4,4'-dicarboxylic acid chloride (72460-28-7) → [2,2']bipyridinyl-4,4'-dicarboxylic acid bis-[2-(2-methoxy-1-methyl-ethoxy)-1-methyl-ethyl] ester (197955-25-2)

Conditions	Yield
Esterification;

propylene glycol monomethyl ether dimer (20324-32-7) → 2-(2-bromo-propoxy)-1-methoxy-propane

Conditions	Yield
With pyridine; phosphorus tribromide

propylene glycol monomethyl ether dimer (20324-32-7) → 4-[2-(2-methoxy-1-methyl-ethoxy)-1-methyl-ethoxy]-benzaldehyde

Conditions	Yield
Multi-step reaction with 2 steps 1: PBr3; pyridine 2: K2CO3 / dimethylformamide View Scheme

propylene glycol monomethyl ether dimer (20324-32-7) → [β-(4-nitro-benzoyloxy)-isopropyl]-[2-(4-nitro-benzoyloxy)-propyl]-ether (857233-30-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous hydrobromic acid View Scheme

propylene glycol monomethyl ether dimer (20324-32-7) → C7H15ClO2

Conditions	Yield
With thionyl chloride; triethylamine In hexane at 15 - 80℃; for 3.5h;	126.3 g

propylene glycol monomethyl ether dimer (20324-32-7) → C11H23NO3

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine; thionyl chloride / hexane / 3.5 h / 15 - 80 °C 2: 10 h / 120 °C View Scheme

propylene glycol monomethyl ether dimer (20324-32-7) → C13H25NO5

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.5 h / 130 °C / Inert atmosphere 2: 12 h / 20 - 85 °C View Scheme

1H-imidazole (288-32-4) + propylene glycol monomethyl ether dimer (20324-32-7) + C7H15ClO2 → C10H18N2O2

Conditions	Yield
Stage #1: propylene glycol monomethyl ether dimer With sodium at 120℃; for 1h; Stage #2: 1H-imidazole at 80 - 120℃; for 2.5h; Stage #3: C7H15ClO2 at 120℃; for 8.75h;	53 g

propylene glycol monomethyl ether dimer (20324-32-7) + chloroacetyl chloride (79-04-9) → C9H17ClO4

Conditions	Yield
at 130℃; for 1.5h; Inert atmosphere;

methylene chloride (74-87-3) + propylene glycol monomethyl ether dimer (20324-32-7) → propylene glycol dimethyl ether dimer

Conditions	Yield
With triethylamine; sodium hydroxide In water at 90 - 100℃; under 75.0075 - 4500.45 Torr; for 2h; Reagent/catalyst; Autoclave; Inert atmosphere;

1,4-bis(2-methyloxiran-2-yl)benzene (17096-88-7) + propylene glycol monomethyl ether dimer (20324-32-7) → 2,2′-(1,4-phenylene)bis(1-((1-((1-methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol)

Conditions	Yield
With potassium hydroxide at 50 - 70℃; Inert atmosphere;
With potassium hydroxide at 50 - 70℃; Inert atmosphere;

Upstream product

• 107-98-2 1-methoxy-2-propanol 
• 75-56-9 methyloxirane 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 

Downstream Products

• 89399-28-0 dipropylene glycol dimethyl ether 
• 857233-30-8 [β-(4-nitro-benzoyloxy)-isopropyl]-[2-(4-nitro-benzoyloxy)-propyl]-ether 
• 106-62-7 Dipropylene glycol 

Relevant articles and documents

PROCESS FOR SPLITTING WATER-SOLUBLE ETHERS

A process for production of 1,3-propanediol including the steps: (a) hydrating acrolein in the presence of an acid hydration catalyst; (b) catalytically hydrogenating the reaction mixture of step (a), which reaction mixture comprises 3-hydroxypropionaldehyde and is freed of unreacted acrolein; (c) refining the reaction mixture of step (b) containing water, 1,3-propanediol and the by-products boiling higher than 1,3-propanediol; and (d) treating 4-oxa-1,7-heptanediol to form 1,3-propanediol by (1) removing a boiler sump comprising 4-oxa-1,7-heptanediol from the refining step (c), (2) treating the boiler sump in an aqueous solution in the presence of an acid catalyst at about 200 to about 300° C. to form a solution comprising 1,3-propanediol, (3) neutralizing the solution obtained is step (2), and returning the neutralized solution from step (3) to the refining step (c). In addition, a process for splitting oligomeric water-soluble ether comprising: (a) treating an aqueous solution comprising oligomeric water-soluble ether in the presence of homogeneous acid catalyst at a temperature of from about 200 to about 300 ° C. to form the monomer of the oligomeric water-soluble ether; and (b) neutralizing the solution obtained in step (a),