2033-30-9

Basic information

• Product Name: 5,6-DIMETHYL-2-BENZIMIDAZOLINONE
• Synonyms: 5,6-DIMETHYLBENZIMIDAZOLONE;5,6-DIMETHYL-2,3-DIHYDRO-2-BENZIMIDAZOLONE;5,6-DIMETHYL-2-HYDROXYBENZIMIDAZOLE;5,6-DIMETHYL-2-BENZIMIDAZOLINONE;5,6-DIMETHYL-1H-BENZO[D]IMIDAZOL-2(3H)-ONE;1,3-dihydro-5,6-dimethyl-2H-benzimidazol-2-one;5,6-Dimethyl-2-benzimidazolinone, 98+%;2H-Benzimidazol-2-one,1,3-dihydro-5,6-dimethyl-(9CI)
• CAS NO: 2033-30-9
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.19
• EINECS: 217-993-3
• Product Categories: BENZIMIDAZOLE
• Mol File: 2033-30-9.mol
• Article Data: 14

Chemical Properties

• Melting Point: >300°C
• Boiling Point: 174 °C at 760 mmHg
• Flash Point: 60.7 °C
• Appearance: /
• Density: 1.161 g/cm³
• Vapor Pressure: 1.23mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.97±0.30(Predicted)
• BRN: 139589
• CAS DataBase Reference: 5,6-DIMETHYL-2-BENZIMIDAZOLINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-DIMETHYL-2-BENZIMIDAZOLINONE(2033-30-9)
• EPA Substance Registry System: 5,6-DIMETHYL-2-BENZIMIDAZOLINONE(2033-30-9)

Safety Data

• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 2033-30-9(Hazardous Substances Data)

Usage

Uses

5,6-Dimethyl-2-benzimidazolinone is a building block for the synthesis of various pharmaceutically and biologically active compounds.

InChI:InChI=1/C9H10N2O/c1-5-3-7-8(4-6(5)2)11-9(12)10-7/h3-4H,1-2H3,(H2,10,11,12)

Upstream product

• 3171-45-7 4,5-dimethyl-1,2-phenylenediamine 
• 57-13-6 urea 
• 530-62-1 1,1'-carbonyldiimidazole 
• 124-38-9 carbon dioxide 
• 610-23-1 4,5-dimethyl-1,2-dinitrobenzene 
• 83-01-2 diphenylcarbamic chloride 
• 917-61-3 sodium isocyanate 
• 103-71-9 phenyl isocyanate 
• 1711-61-1 5-(4-chlorophenyl)-3H-[1,3,4]oxadiazol-2-one 
• 70254-61-4 4-hydroxy-6-methyl-2H-pyran-2-one 
• 71-36-3 butan-1-ol 
• 582-60-5 5,6-dimethyl-1H-benzo[d]imida-zole 

Downstream Products

• 39791-96-3 2-chloro-5,6-dimethyl-1H-benzo[d]imidazole 
• 184832-31-3 2-chloro-5,6-dimethyl-1-(phenylmethyl)-1H-benzimidazole 
• 39791-97-4 2-chloro-1,5,6-trimethyl-1H-benzo[d]imidazole 

Relevant articles and documents

PrVO4/SnD NPs as a Nanocatalyst for Carbon Dioxide Fixation to Synthesis Benzimidazoles and 2-Oxazolidinones

Recently CO2 stabilization has received a great deal of attention because of its probable applications as a rich C1 resource and the synthesis of several fine chemicals can be accomplished through this stabilization. In this study, Sn(IV) doping dendritic fibrous nanosilica (SnD) supported PrVO4 nanoparticles as a catalyst (PrVO4/SnD) was synthesized by a in-situ procedure. The SnD with the ratios of Si/Sn in a variety of 6 to 40 were acquired through direct hydrothermal synthesis (DHS), and PrVO4 NPs on the surfaces of SnD were reduced in-situ. X-Ray diffraction (XRD), Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), and X-ray energy dispersive spectroscopy (EDS) were deployed for identifying the PrVO4/SnD. It is potentially a highly dynamic catalyst in the stabilization of CO2 for the production of 2-oxazolidinones and benzimidazoles. In addition, the catalyst is very easy to recycle and reuse without significant loss of active site Cu metal. Graphic Abstract: PrVO4/SnD NPs as a nanocatalyst for carbon dioxide fixation to synthesis benzimidazoles and 2-oxazolidinones. [Figure not available: see fulltext.]

Application of sea urchin-shaped cobalt-based photocatalyst in synthesis of benzoazacycle by converting CO2

The invention relates to the technical field of photocatalysis, in particular to application of a sea urchin-shaped cobalt-based photocatalyst to synthesis of benzoazacycle by converting CO2. A complex is of a sea urchin-shaped microsphere structure, which is composed of an organic ligand L and cobalt nitrate hexahydrate and is formed by arranging a plurality of nano needle-shaped complex crystals. The main body of the organic ligand L is p-aminobenzoic acid; the application comprises the following steps: introducing CO2 into a solution containing o-phenylenediamine compounds, carrying out carbonylation reaction and cyclization with o-phenylenediamine compounds under the action of the urchin-shaped cobalt-based catalyst to generate the benzoazacycle compounds. The sea urchin-shaped microsphere structure cobalt-based catalyst formed by the obtained nano needle-shaped complex crystal has a very large specific surface area and high photocatalytic efficiency; when the photocatalyst is adopted to catalyze and activate CO2, the reaction for synthesizing the benzoazacycle by converting CO2 can be carried out at room temperature, so that the energy consumption is greatly reduced, and the cost is reduced.

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

Son of sevenless homologue 1 (SOS1) is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS. In its active form, GTP-bound RAS is responsible for numerous critical cellular processes. Aberrant RAS activity is involved in ～30% of all human cancers; hence, SOS1 is an attractive therapeutic target for its role in modulating RAS activation. Here, we describe a new series of benzimidazole-derived SOS1 agonists. Using structure-guided design, we discovered small molecules that increase nucleotide exchange on RAS in vitro at submicromolar concentrations, bind to SOS1 with low double-digit nanomolar affinity, rapidly enhance cellular RAS-GTP levels, and invoke biphasic signaling changes in phosphorylation of ERK 1/2. These compounds represent the most potent series of SOS1 agonists reported to date.