20335-99-3

Basic information

• Product Name: (Sp)-benzylphenylphosphine oxide
• CAS NO: 20335-99-3
• Molecular Weight: 216.219
• Mol File: 20335-99-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (Sp)-benzylphenylphosphine oxide(CAS DataBase Reference)
• NIST Chemistry Reference: (Sp)-benzylphenylphosphine oxide(20335-99-3)
• EPA Substance Registry System: (Sp)-benzylphenylphosphine oxide(20335-99-3)

Safety Data

• Hazardous Substances Data: 20335-99-3(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 638-21-1 phenylphosphane 
• 1589-82-8 phenylmagnesium bromide 
• 31352-60-0 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl phenylphosphinate 
• 591-51-5 phenyllithium 
• 172487-18-2 ethyl Phenylphosphinate 
• 6921-34-2 benzylmagnesium chloride 
• 644-97-3 Dichlorophenylphosphine 
• 32395-29-2 benzylphenylphosphinous acid chloride 
• 90826-94-1 C₁₄H₁₂NP 

Downstream Products

• 57564-38-2 2,2,4-trimethyl-1,5-diphenyl-2,3-dihydro-1H-phosphole 1-oxide 
• 40203-60-9 4-methyl-1-oxo-1,2-diphenyl-1λ⁵-phospholan-3-one 
• 109632-25-9 C₁₆H₁₇OP 
• 109632-26-0 C₁₇H₁₉OP 
• 109632-27-1 C₂₁H₁₉OP 
• 75354-30-2 1,1-Bis(benzylphenylphosphinyl)-2,2,2-trifluorethanol 
• 109632-28-2 (E)-3-(Benzyl-phenyl-phosphinoyl)-2-methyl-acrylic acid methyl ester 
• 1344732-73-5 benzylphenyl(2-pyridylmethyl)phosphine oxide 
• 13238-16-9 dibenzylphosphine oxide 
• 24442-45-3 dibenzylphenylphosphane oxide 
• 1344732-74-6 benzyl(methoxymethyl)phenylphosphine oxide 
• 33838-34-5 methylbenzylphenylphosphine oxide 

Relevant articles and documents

Stereo- And Regioselective cis-Hydrophosphorylation of 1,3-Enynes Enabled by the Visible-Light Irradiation of NiCl2(PPh3)2

Described herein is a stereo- and regioselective cis-hydrophosphorylation reaction of the internal alkyne of 1,3-enynes that accesses various 1,3-dienes in good isolated yields. The visible-light irradiation of NiCl2(PPh3)2 allows the generation of highly reactive nickel(II)-phosphorus species that subsequently migrate into the internal alkyne of the 1,3-enynes and protonate the resulting vinyl nickel species, leading to various phosphinoyl 1,3-butadienes under mild reaction conditions.

Single-step synthesis of secondary phosphine oxides

We report that in the presence of trifluoroacetic acid primary phosphines undergo efficient addition to aldehydes to form the corresponding secondary phosphine oxides in 47-97% yield. This transformation is compatible with aryl and alkyl phosphines, as well as a broad range of aldehydes, including formaldehyde. By using 1,5-dialdehydes as reaction partners, the addition provides a straightforward route to bis(phosphine oxides), which are difficult to prepare by alternative methods. In the presence of boron trifluoride diethyl etherate as reagent, benzophenone was shown to couple to phenylphosphine and cyclohexylphosphine in 92% and 72% yield, respectively. Twenty-three examples are presented.

Stereospecific nucleophilic substitution of optically pure H-phosphinates: A general way for the preparation of chiral P-stereogenic phosphine oxides

Contrary to the generally held view, it is found that the rapid epimerization of (-)-menthyl (RP)-phenylphosphinate under basic conditions is not due to the so far believed inherent stereolability of its corresponding anion but due to a reactio