2034-65-3

Basic information

• Product Name: 3,7,4'-TRIHYDROXYFLAVONE
• Synonyms: RESOKAEMPFEROL;RESOKAEMPFEROL-3,7,4'-TRIHYDROXYFLAVONE;3,7,4'-TRIHYDROXYFLAVONE;5-DEOXYKAEMPFEROL;DEOXYKAEMPFEROL, 5-;DEOXYKAEMPFEROL, 5-(SH);(3,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE) (RESOKAEMPFEROL);2-(4-Hydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
• CAS NO: 2034-65-3
• Molecular Formula: C₁₅H₁₀O₅
• Molecular Weight: 270.24
• Product Categories: Flavanols
• Mol File: 2034-65-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 310-311°C
• Boiling Point: 539.7°Cat760mmHg
• Flash Point: 210.6°C
• Appearance: /
• Density: 1.579g/cm³
• Vapor Pressure: 1.76E-12mmHg at 25°C
• Refractive Index: 1.747
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 6.85±0.40(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 3,7,4'-TRIHYDROXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,7,4'-TRIHYDROXYFLAVONE(2034-65-3)
• EPA Substance Registry System: 3,7,4'-TRIHYDROXYFLAVONE(2034-65-3)

Safety Data

• Hazardous Substances Data: 2034-65-3(Hazardous Substances Data)

Usage

General Description

3,7,4'-Trihydroxyflavone, also known as luteolin, is a naturally occurring flavonoid found in many plants, including celery, parsley, and chamomile. It has been extensively studied for its potential therapeutic properties, including anti-inflammatory, antioxidant, and anticancer effects. 3,7,4'-Trihydroxyflavone has also been shown to inhibit the growth of cancer cells and induce apoptosis, making it a promising candidate for cancer treatment. Additionally, it has been found to have neuroprotective effects, potentially benefiting those with neurodegenerative diseases. Overall, 3,7,4'-Trihydroxyflavone has demonstrated a wide range of potential health benefits and is an area of ongoing research for its medicinal properties.

InChI:InChI=1/C15H10O5/c16-9-3-1-8(2-4-9)15-14(19)13(18)11-6-5-10(17)7-12(11)20-15/h1-7,16-17,19H

Upstream product

• 57280-75-8 2',4'-dihydroxy-2-methoxyacetophenone 
• 13198-99-7 3-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 2198-19-8 2'-hydroxy-4,4'-dimethoxychalcone 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 492-00-2 3,7-dihydroxyflavone 
• 578-86-9 liquiritigenin 
• 60-18-4 L-tyrosine 
• 794-94-5 p-Methoxybenzoic anhydride 
• 961-29-5 isoliquirtigenin 
• 78430-12-3 3,4'-dimethoxy-7-hydroxyflavone 

Downstream Products

• 528-48-3 3,7,3',4'-tetrahydroxyflavone 
• 1242087-66-6 Resokaempferol 3-glucuronide 
• 1242087-79-1 C₂₁H₁₈O₁₁ 
• 804436-59-7 C₁₅H₁₀O₈S 

Relevant articles and documents

MICROBIAL PRODUCTION OF THE FLAVONOIDS GARBANZOL, RESOKAEMPFEROL AND FISETIN

The invention provides a genetically modified micro-organism comprising one or more transgene for the production of one or more of the flavonoids garbanzol, resokaempferol and fisetin. The micro-organism may be a bacterial or yeast cell engineered to express a metabolic pathway for garbanzol, resokaempferol and/or fisetin biosynthesis. The invention further provides a method for producing garbanzol, resokaempferol and/or fisetin employing the genetically modified micro-organism of the invention. The genetically modified micro- organism may be used to convert a number of substrates and/or co-substrates into fisetin via a fisetin biosynthetic pathway.

Selective synthesis of functional alkynylmono- and -trisilanes

The selective synthesis of functional alkynylsllanes RC=C(SiMe 2)m,-X (m = 1, 3) was investigated. Monofunctionalization with or without protecting groups gave moderate to good yields of alkynyldimethylmonosilanes RC=CMe2SiX [R = Ph, X = Cl. (1), NEt 2 (2), OMe (3), H (4), Br (5), I (6), Cp (8), C5H 4Li (10), Ph (11); R = Pr, X = Ph (12)]. Compounds 4 and 8 were converted into the (alkyne)transition-metal complexes 4-Cp2Mo 2(CO)4 (13) and 8-Co2(CO)6 (14), respectively, which were characterized by X-ray diffraction. Stepwise extension and functionalization of the silane chain starting from 1chloro-2-(diethylamino) tetramethyldisilane (Et2NMe2Si-SiMe2Cl) yielded the trisilanes Ph-(SiMe2J3-X [X = NEt2 (18), OMe (19), Cl (20), H (21), C=CPh (22), C=CPr (23)]. The synthesized compounds were characterized by NMR and IR spectroscopy, 4, 11, 13, and 14 also by UV/Vis spectroscopy.