203662-19-5

Basic information

• Product Name: tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate
• Synonyms: tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate
• CAS NO: 203662-19-5
• Molecular Formula: C₁₃H₂₁NO₄
• Molecular Weight: 255.31014
• Mol File: 203662-19-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate(203662-19-5)
• EPA Substance Registry System: tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate(203662-19-5)

Safety Data

• Hazardous Substances Data: 203662-19-5(Hazardous Substances Data)

Usage

General Description

Tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate is a highly complex chemical compound with a unique and intricate molecular structure. It is a carboxylate ester containing a tert-butyl group and a 3-oxo-2-oxa-8-azaspiro[4.5]decane moiety. tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate has potential applications in the pharmaceutical and agrochemical industries due to its spirocyclic structure, which can potentially exhibit interesting biological activity. The presence of functional groups like the carboxylate ester and the oxo group also make this compound a valuable building block for the synthesis of more complex molecules. Its specific properties and potential uses in various industries make tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate an interesting and important chemical compound for further research and development.

Upstream product

• 203662-20-8 8-t-butoxycarbonyl-3-hydroxy-2-oxa-8-azaspiro[4.5]decane 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 236406-37-4 tert-butyl 4-(hydroxymethyl)-4-(prop-2-en-1-yl)piperidine-1-carboxylate 
• 203661-69-2 tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate 
• 441774-09-0 1-(tert-butyl) 4-methyl 4-allylpiperidine-1,4-dicarboxylate 

Downstream Products

• 441774-11-4 4-carboxymethyl-4-(4-hydroxy-phenylsulfanylmethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 441774-14-7 4-methoxycarbonylmethyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: Identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4. 5]decane as lead scaffolds

Herein we report the identification of two new fatty acid amide hydrolase (FAAH) inhibitor lead series with FAAH kinact/Ki potency values greater than 1500 M-1s-1. The two novel spirocyclic cores, 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane, clearly distinguished themselves from the other spirocyclic cores on the basis of their superior potency for FAAH. Lead compounds from these two series have suitable FAAH potency and selectivity for additional medicinal chemistry optimization.

Phthalazine derivatives and remedies for erectile dysfunction

The present invention provides a phthalazine compound as a therapeutic agent for erectile dysfunction represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: wherein R1and R2are the same as or different from each other and represent a halogen atom, a C1 to C4 alkyl group which may be substituted with a halogen atom, a C1 to C4 alkoxy group which may be substituted with a halogen atom or a cyano group; X represents a cyano group, a nitro group, a halogen atom, a hydroxyimino group which may be substituted or a heteroaryl group which may be substituted; Y represents a heteroaryl group, an aryl group which may be substituted, an alkynyl group which may substituted, an alkenyl group, an alkyl group, an optionally substituted saturated or unsaturated 4- to 8-membered amine ring, and the cyclic amine compound is a monocyclic compound, bicyclic compound or a spiro compound; l is an integer of 1 to 3; provided that the case where l is 1 or 2, X is a cyano group, a nitro group or a chlorine atom, R1is a chlorine atom, R2is a methoxy group and Y is a 5- or 6-membered amine ring substituted with a hydroxyl group is excluded.