204002-77-7

Basic information

• Product Name: Benzoic acid (2R,3aR,4R,5S)-2-(2-hydroxy-ethyl)-5-(2-methoxy-ethoxymethoxy)-hexahydro-pyrrolo[1,2-b]isoxazol-4-yl ester
• CAS NO: 204002-77-7
• Molecular Weight: 381.426
• Mol File: 204002-77-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid (2R,3aR,4R,5S)-2-(2-hydroxy-ethyl)-5-(2-methoxy-ethoxymethoxy)-hexahydro-pyrrolo[1,2-b]isoxazol-4-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid (2R,3aR,4R,5S)-2-(2-hydroxy-ethyl)-5-(2-methoxy-ethoxymethoxy)-hexahydro-pyrrolo[1,2-b]isoxazol-4-yl ester(204002-77-7)
• EPA Substance Registry System: Benzoic acid (2R,3aR,4R,5S)-2-(2-hydroxy-ethyl)-5-(2-methoxy-ethoxymethoxy)-hexahydro-pyrrolo[1,2-b]isoxazol-4-yl ester(204002-77-7)

Safety Data

• Hazardous Substances Data: 204002-77-7(Hazardous Substances Data)

Upstream product

• 204002-64-2 (3S,4S)-1-Benzyl-4-(2-methoxy-ethoxymethoxy)-pyrrolidin-3-ol 
• 204002-72-2 Benzoic acid (3R,4S)-4-(2-methoxy-ethoxymethoxy)-pyrrolidin-3-yl ester 
• 204002-66-4 Benzoic acid (3R,4S)-1-benzyl-4-(2-methoxy-ethoxymethoxy)-pyrrolidin-3-yl ester 
• 627-27-0 homoalylic alcohol 
• 204002-75-5 Benzoic acid (3R,4S)-4-(2-methoxy-ethoxymethoxy)-1-oxy-4,5-dihydro-3H-pyrrol-3-yl ester 

Relevant articles and documents

Formal desymmetrization by a "Mitsunobu trick" - Enantiomerically pure cis-3,4-Dihydroxypyrroline N-oxides for the enantiodivergent synthesis of trihydroxyindolizidines

A protocol is presented for a completely enantioselective formal desymmetrization of Cs-symmetric diols by monoproteclion of the corresponding enanliopure C2 diols, followed by an inversion of configuration by a Mitsunobu reaction ("Mitsunobu trick"). Its application to the unprecedented synthesis of enantiopure cis-3,4-dihydroxypyrroline N-oxides, employed in the enantiodivergent synthesis of two selectively protected 1,2,7-trihydroxyindolizidines, is also reported.